What is off target toxicity?
Table of Contents
What is off target toxicity?
Describes the effects that can occur when a drug binds to targets (proteins or other molecules in the body) other than those for which the drug was meant to bind. This can lead to unexpected side effects that may be harmful.
What are small molecule drugs for cancer?
List of small molecule inhibitors for cancer therapy
| Molecular Target | Small Molecule Drug | Cancer Targeted |
|---|---|---|
| 1.Tyrosine & serine/threonine Kinases | Gefitinib (Iressa) | Non small cell lung cancer |
| Erlotinib (Tarceva) | Non small cell lung cancer, pancreatic cancer | |
| Sunitinib (sutent) | Renal cell carcinoma | |
| Lapatinib (Tykerb) | Breast cancer |
What is an on-target side effect?
On-target side effects refer to the pharmacodynamic effect on normal tissues that occurs when the target that’s being inhibited in the tumor is also being inhibited in the normal tissue.
Is aspirin a small molecule drug?
Aspirin, one of the common over-the-counter medications, is an example of a small molecule drug (see Figure 3).
How do you stop angiogenesis?
Researchers developed drugs called angiogenesis inhibitors, or anti-angiogenic therapy, to disrupt the growth process. These drugs search out and bind themselves to VEGF molecules, which prohibits them from activating receptors on endothelial cells inside blood vessels. Bevacizumab (Avastin®) works in this manner.
Why has cancer become more common?
The main reason cancer risk overall is rising is because of our increasing lifespan. And the researchers behind these new statistics reckon that about two-thirds of the increase is due to the fact we’re living longer. The rest, they think, is caused by changes in cancer rates across different age groups.
Are vitamins small molecules?
Most vitamins are not single molecules, but groups of related molecules called vitamers. For example, there are eight vitamers of vitamin E: four tocopherols and four tocotrienols.
Is insulin a small molecule drug?
Biologic medication: Biologic medications are large, complex molecules, often made from living cells or tissue. Insulin, Victoza® and Trulicity® are examples of biologic medications that help manage diabetes. Drugs: Drugs are smaller molecules that are made through a chemical process.
