What miRNA 31?
Table of Contents
What miRNA 31?
This review summarizes the functional roles and transcriptional regulation of the highly evolutionarily conserved miRNA, microRNA-31 (miR-31). miR-31 is an important regulator of embryonic implantation, development, bone and muscle homeostasis, and immune system function.
What is the function of miR?
miR-590 plays a role of oncogenes or tumor suppressor and regulates cell differentiation, proliferation, apoptosis, other physiological and pathological process, and thus becomes an important molecular marker for disease diagnosis, treatment and prognosis.
What is miR 34a?
MiR-34a can control the expression of many target genes through their mRNAs and, thus, can be implicated in a plethora of important biological processes, particularly in cell proliferation, differentiation, apoptosis, and regulation of migration [7,21,33,34].
Where are miRNA genes found?
the genome
Transcription. miRNA genes are located throughout the genome[15]. Many miRNA genes are noncoding genes whose sole transcriptional product is the miRNA. In other cases the miRNA is located within an intron or untranslated region (UTR) of a protein coding gene.
How does miRNA inhibit gene expression?
How microRNA controls gene expression. microRNA controls gene expression mainly by binding with messenger RNA (mRNA) in the cell cytoplasm. Instead of being translated quickly into a protein, the marked mRNA will be either destroyed and its components recycled, or it will be preserved and translated later.
What is the meaning of miRNA?
(MY-kroh …) A type of RNA found in cells and in blood. MicroRNAs are smaller than many other types of RNA and can bind to messenger RNAs (mRNAs) to block them from making proteins. MicroRNAs are being studied in the diagnosis and treatment of cancer. Also called miRNA.
How miRNA is produced?
MicroRNAs are transcribed by RNA polymerases II and III, generating precursors that undergo a series of cleavage events to form mature microRNA. The conventional biogenesis pathway consists of two cleavage events, one nuclear and one cytoplasmic.
What is the role of microRNA in gene expression?
microRNA controls gene expression mainly by binding with messenger RNA (mRNA) in the cell cytoplasm. Instead of being translated quickly into a protein, the marked mRNA will be either destroyed and its components recycled, or it will be preserved and translated later.
