Which antibodies ITP?

Which antibodies ITP?

Primary immune thrombocytopenia (ITP) is an autoimmune disease mediated by antiplatelet autoantibodies that cause increased platelet clearance. Most of these antibodies are directed against platelet membrane glycoprotein (GP) complexes, GPIIb/IIIa (CD41/CD61) or GPIbIX (CD42b and CD42a).

What is neonatal alloimmune thrombocytopenia?

Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a rare disorder (1 out of 1000 births) in which maternal-fetal platelet incompatibility leads to formation of maternal antibodies that result in fetal and neonatal thrombocytopenia. Platelet function remains relatively normal.

What is ITT disease?

Idiopathic thrombocytopenic purpura is a blood disorder characterized by an abnormal decrease in the number of platelets in the blood.

Is Coombs test positive in ITP?

In such cases, a negative antinuclear antibody (ANA) result is useful in diagnosing ITP if the patient’s thrombocytopenia becomes chronic and resistant to treatment. If anemia and thrombocytopenia are present, a positive direct antiglobulin (Coombs) test result may help establish a diagnosis of Evans syndrome.

Who discovered ITP?

The experiment was undertaken in 1950 by William J. Harrington and James W. Hollingsworth, who postulated that in patients with idiopathic thrombocytopenic purpura (ITP), it was a blood factor that caused the destruction of platelets. To test this hypothesis, Harrington received 500 ml of blood from a patient with ITP.

What is NAIT testing?

The primary tests for neonatal alloimmune thrombocytopenia (NAIT) are an initial CBC with platelet count to confirm thrombocytopenia, followed by a maternal serum test for platelet alloantibodies. (Neonatal samples are discouraged for circulating antibody testing due to insensitivity.

What is platelet antibody test?

Definition. This blood test shows if you have antibodies against platelets in your blood. Platelets are a part of the blood that helps the blood clot.

When was ITP founded?

Purpura, initially recognized in ancient times, was defined into clinical syndromes in the 16th, 17th and 18th centuries. With advances in microscope science in the nineteenth century, the platelet was identified, leading to the recognition of the thrombocytopenic component of idiopathic thrombocytopenic purpura (ITP).

Is Coombs positive in ITP?

How is TTP diagnosed?

To diagnose TTP, your provider will ask about your medical and family history. They will ask about your symptoms and do a physical exam to look for signs of TTP. Your provider may order one or more of the blood tests listed below. ADAMTS13 assay: A lack of activity in the ADAMTS13 enzyme causes TTP.

What is history of ITP?

What is the pathophysiology of ITP?

The pathophysiology of ITP is complex and abnormalities of both the B-cell and the T-cell compartments have been identified. The mechanisms of the thrombocytopenia involve both increased platelet destruction and, in a significant proportion of cases, impaired platelet production.

How is NAIT treated?

Currently, the mainstay of therapy includes maternal administration of intravenous immunoglobulin (IVIG), with or without steroids. Intravenous human immunoglobulin (IVIG) has proven to be the most successful treatment for fetal and neonatal alloimmune thrombocytopenia.

What is HPA 1a?

The most common platelet specific antibody implicated in alloimmune thrombocytopenia is HPA-1a; however there are other high frequency antigens that antigen negative recipients can form antibodies against leading to alloimmune thrombocytopenia.

What is Maipa and how does it work?

Monoclonal Antibody-specific Immobilization of Platelet Antigen (MAIPA) is a qualitative technique for platelet antibody detection and/or identification. It is considered to be the gold standard method in the platelet immunology field. apDia offers all cells, control plasma, reagents and materials necessary to perform the MAIPA procedure.

What is the best thrombocyte reagent for Maipa?

These apDia thrombocyte reagents are especially recommended for the MAIPA procedure and are advantageous for standardization, handling and workflow organization in the platelet immunology laboratory. The human thrombocytes are typed for HPA-1, -2, -3, -4, -5, -6 and -15.

Why choose apdia for your Maipa?

It is considered to be the gold standard method in the platelet immunology field. apDia offers all cells, control plasma, reagents and materials necessary to perform the MAIPA procedure. The products are either offered as a complete MAIPA kit or as separate modules allowing ordering reagents for defined steps of the MAIPA procedure (below).