How is differentiation syndrome treated?
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How is differentiation syndrome treated?
Because of the life-threatening nature of the full-blown syndrome, a preemptive use of corticosteroids at the very earliest symptom or sign suggestive of DS has been adopted as the standard management (Figure 1B). Dexamethasone, at a dose of 10 mg twice daily by intravenous injection, is the most common treatment.
What is an ATRA patient?
ATRA and ATO therapy is a combination treatment of all- trans retinoic acid (ATRA) and arsenic trioxide (ATO) which is now recognised as the first-line treatment for acute promyelocytic leukaemia (APL). A first-line treatment is accepted as the best initial treatment for a given type and stage of a disease.
How does ATRA work in APL?
All-Trans Retinoic Acid (ATRA) This drug, a vitamin A derivative, has become a standard component of induction therapy for APL. ATRA targets and eliminates the PML/RARĪ± abnormality. This treatment causes a marked decrease in the concentration of leukemic blast cells in the marrow, and a remission frequently follows.
What is ATRA in AML?
Conclusion: All-trans retinoic acid (ATRA) can enhance the anti-leukemia effect of ABT-199 on AML cell lines by inhibiting cell proliferation as seen by the cell cycle arrest of AML cells in G1 phase, promoting apoptosis and inducing differentiation.
What are the side effects of ATRA?
Side effects of ATRA or arsenic trioxide
- difficulty breathing.
- fever.
- weight gain.
- swelling (caused by fluid build-up)
- low blood pressure.
- coughing.
- chest pain.
- feeling unusually tired or weak.
What does ATRA do in APL?
How long is ATRA therapy?
The most common options for maintenance therapy are ATRA alone, or ATRA along with chemo (6-mercaptopurine (6-MP) and/or methotrexate). Maintenance therapy is typically given for about a year.
How is APL diagnosed?
Doctors use the results of the blood and bone marrow tests to identify the abnormal APL cells. A prompt diagnosis of APL is vital because appropriate treatment must be started immediately in order to avoid the serious and potentially life-threatening complications associated with the disease.
What is ATRA for APL?
ATRA. ATRA is a form of vitamin A that is typically part of the initial (induction) treatment of APL. It is given either along with chemo, or along with arsenic trioxide for the initial treatment of APL.
Does ATRA cause hair loss?
Trisenox has no known cross-resistance with ATRA or other anticancer agents. It does not cause hair loss and is not myelosuppressive in patients with APL.
Is ATRA a chemotherapy?
ATRA is an anti-cancer (“antineoplastic” or “cytotoxic”) chemotherapy drug.
How does ATRA work in AML?
