Is there a genetic link to osteosarcoma?
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Is there a genetic link to osteosarcoma?
Most osteosarcomas are not caused by inherited gene mutations, but instead are the result of gene changes acquired during the person’s lifetime. Sometimes these gene changes are caused by radiation therapy used to treat another form of cancer, because radiation can damage the DNA inside cells.
What genes are mutated in osteosarcoma?
Osteosarcoma is a feature of Li-Fraumeni syndrome-1 (LFS1; 151623), caused by mutation in the TP53 gene (191170), and of Li-Fraumeni syndrome-2 (LFS2; 609265), caused by mutation in the CHEK2 gene (604373). Sporadic osteosarcoma has also been associated with mutations in the CHEK2 gene (604373.0005).
Can bone cancer be inherited?
Heredity. A small number of bone cancers are due to heredity. For example, children with hereditary retinoblastoma (an uncommon cancer of the eye) are at a higher risk of developing osteosarcoma.
What type of cancer is osteosarcoma?
Osteosarcoma is a type of bone cancer that begins in the cells that form bones. Osteosarcoma is most often found in the long bones — more often the legs, but sometimes the arms — but it can start in any bone. In very rare instances, it occurs in soft tissue outside the bone.
Who is most likely to get osteosarcoma?
The risk of osteosarcoma is highest for those between the ages of 10 and 30, especially during the teenage growth spurt. This suggests there may be a link between rapid bone growth and risk of tumor formation. The risk goes down in middle age, but rises again in older adults (usually over the age of 60).
What is the main cause of osteosarcoma?
What causes osteosarcoma? The exact cause of osteosarcoma is not known, but it is believed to be due to DNA mutations inside bone cells—either inherited or acquired after birth.
Who is most at risk for osteosarcoma?
Age. The risk of osteosarcoma is highest for those between the ages of 10 and 30, especially during the teenage growth spurt. This suggests there may be a link between rapid bone growth and risk of tumor formation. The risk goes down in middle age, but rises again in older adults (usually over the age of 60).
Is osteosarcoma cancer curable?
Today, about 3 out of 4 people who have osteosarcoma can be cured if the cancer hasn’t spread to other parts of the body. Almost everyone who is treated with limb-sparing surgery ends up with that arm or leg working well. Many people who have osteosarcoma will need physical therapy for several months after surgery.
What increases risk of osteosarcoma?
Who is at greatest risk for osteosarcoma?
Can osteosarcoma be cured?
How can you prevent osteosarcoma?
Osteosarcoma Prevention While it is always good to maintain a healthy weight and to quit smoking or using tobacco, currently, there are no known lifestyle changes that can prevent osteosarcoma.
How long can I live with osteosarcoma?
They can’t tell you how long a person will live, but they may help give you a better understanding of how likely it is that treatment will be successful….5-year relative survival rates for osteosarcoma.
| SEER stage | 5-year relative survival rate |
|---|---|
| Localized | 77% |
| Regional | 65% |
| Distant | 26% |
| All SEER stages combined | 60% |
How long do osteosarcoma patients live?
Survival rates can give you an idea of what percentage of people with the same type and stage of cancer are still alive a certain amount of time (usually 5 years) after they were diagnosed….5-year relative survival rates for osteosarcoma.
| SEER stage | 5-year relative survival rate |
|---|---|
| Distant | 26% |
| All SEER stages combined | 60% |
What is the life expectancy of someone with osteosarcoma?
