What does glomerular tuft mean?

What does glomerular tuft mean?

The glomerular tuft is a network of capillaries within the glomerulus, that performs the first step in blood filtration within the kidney.

What are glomerular crescents?

INTRODUCTION AND DEFINITION. Cellular glomerular crescents are defined as two or more layers of proliferating cells in Bowman’s space (picture 1 and picture 2) and are a hallmark of inflammatory glomerulonephritis and a histologic marker of severe glomerular injury. Crescents can be circumferential or segmental.

What is mesangium in the kidney?

The Mesangium: Cells and Matrix. The mesangium with its associated cells and matrix is an arborizing structure that supports the glomerular capillary loops but is continuous with the JGA that lies at the junction of the afferent and efferent arterioles and the macula densa of the distal tubule.

What is Endotheliosis glomerular?

“Glomerular endotheliosis” represents a specific variant of thrombotic microangiopathy that is characterized by glomerular endothelial swelling with loss of endothelial fenestrae and occlusion of the capillary lumens. Associated thrombosis is unusual.

What is Endotheliosis?

Endotheliosis is defined by endothelial changes in renal glomeruli, combining swollen endothelial cells leading to narrowed capillary lumen (A,B). Foci of acute tubular necrosis are present (C).

What are glomerular crescents and where do they develop?

Cellular glomerular crescents are defined as two or more layers of proliferating cells in Bowman’s space (picture 1 and picture 2) and are a hallmark of inflammatory glomerulonephritis and a histologic marker of severe glomerular injury. Crescents can be circumferential or segmental.

What is nodular glomerulosclerosis?

Introduction. Nodular glomerulosclerosis is a pathological finding characterized by areas of marked mesangial expansion with accentuated glomerular nodularity on renal biopsy. It was originally described by Kimmelstiel and Wilson as a pathognomonic feature of diabetic nephropathy.

Is the mesangium the basement membrane?

Since the mesangial cells are connected to the basement membrane (4) the mesangial cells have been suggested to have a role in regulating the dimension of the glomerular capillaries by changing the extent of the MC-glomerular basement membrane connection (12, 13).

What is acute Atherosis?

Acute atherosis is unique vascular changes of the placenta associated with poor placentation. It is characterized by subendothelial lipid-filled foam cells, fibrinoid necrosis of the arterial wall, perivascular lymphocytic infiltration, and it is histologically similar to early-stage atherosclerosis.

What is glomerular preeclampsia?

Preeclampsia is a pregnancy-specific disorder that complicates approximately 5% of all pregnancies, making it perhaps the most common glomerular disease in the world. It is characterized by new-onset hypertension and proteinuria, in association with a characteristic glomerular lesion, endotheliosis.

What causes endothelial dysfunction?

Endothelial dysfunction can be caused by several conditions, including diabetes or metabolic syndrome, hypertension, smoking, and physical inactivity [20]. The healthy endothelium not only arbitrates endothelium-dependent vasodilation, but also actively suppresses thrombosis, vascular inflammation, and hypertrophy.

What is crescent formation?

A crescent is made up of proliferating epithelial cells that line the Bowman capsule and infiltrating macrophages. It is a marker of severe glomerular injury. The crescents may be circumferential or noncircumferential, and the presence of circumferential crescents in over 80% of glomeruli portends a poor prognosis.