What is EpCAM Antibody?
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What is EpCAM Antibody?
Description: EpCAM (Epithelial cell adhesion molecule, CD326, KSA, TROP1) is a 40 kD cell-surface adhesion molecule participating in homophilic, calcium-independent cell-cell interactions. EpCAM is a type-I transmembrane protein, and is expressed primarily on the basolateral surface of most epithelia.
What is the EpCAM gene?
The EPCAM gene provides instructions for making a protein known as epithelial cellular adhesion molecule (EpCAM). This protein is found in epithelial cells, which are the cells that line the surfaces and cavities of the body.
What is EpCAM positive cells?
EpCAM was originally identified as a tumor-associated antigen on the basis of its high expression level in the tumors of epithelial origin (16). EpCAM-positive cells have been suggested to serve as cancer stem cells for various human cancers, including colorectal and hepatocellular carcinoma (21,22).
What is CD44 a marker for?
CD44 cleavage, shedding, and elevated levels of soluble CD44 in the serum of patients is a marker of tumor burden and metastasis in several cancers including colon and gastric cancer. Recent observations have shown that CD44 intracellular domain (CD44-ICD) is related to the metastatic potential of breast cancer cells.
What is EpCAM a marker for?
The epithelial cell adhesion molecule (EpCAM, CD326) is a glycoprotein of ∼40 kd that was originally identified as a marker for carcinoma, attributable to its high expression on rapidly proliferating tumors of epithelial origin.
How does EpCAM cause Lynch syndrome?
EPCAM deletions lead to a transcriptional read-through, silencing MSH29 and are estimated to cause Lynch syndrome in ∼20–25% of patients with MSH2-negative cancers, but no detectable MSH2 germline mutation. This corresponds to ∼2–3% of Lynch syndrome patients.
What is CD44 +/ CD24?
CD44/CD24 ratio positively correlates with cell proliferation and tumorigenesis. (A,B) The cell proliferation potential of different breast cancer cell lines as indicated by the expression of Ki67. Cells with high CD44/CD24 ratio exhibit high proliferation potential.
Where is CD44?
CD44 standard isoform was originally isolated from hematopoietic cells but now it is found in a variety of tissues e.g., central nervous system, lung, and epidermis. In comparison, the distribution of CD44 variant isoforms is restricted and expressed on a selection of epithelial cells (Sneath and Mangham, 1998).
What is EpCAM staining?
Epithelial cell adhesion molecule (EpCAM) is a transmembrane protein expressed at intercellular junctions in epithelial cells. As an epithelial biomarker, it used for immunologic-based capture of epithelial-derived circulating tumor cells (CTCs) in human patients with different carcinomas.
What is CD24 a marker for?
CD24 expression is a marker for predicting clinical outcome and regulates the epithelial-mesenchymal transition in ovarian cancer via both the Akt and ERK pathways.
What gene is CD44?
CD44 Gene – CD44 Molecule (Indian Blood Group) It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation…
Do neutrophils express CD24?
CD24 is highly expressed on neutrophils, but little is known about its modulation during infection and inflammation.
What is the role of CD44?
Known functions of CD44 are cellular adhesion (aggregation and migration), hyaluronate degradation, lymphocyte activation, lymph node homing, myelopoiesis and lymphopoiesis, angiogenesis, and release of cytokines. The functions of CD44 are principally dependant on cellular adhesion in one setting or another.
What are the signs of Lynch syndrome?
Share on Pinterest Stomach pain and constipation are symptoms of Lynch syndrome. People who have Lynch syndrome can develop noncancerous growths in the colon. These benign growths are also called polyps. People with Lynch syndrome may develop colon polyps at an earlier age than people without this condition.
What is CD24 used for?
Introduction. The heat-stable antigen (mouse CD24) was identified 30 years ago. Since then, CD24 has been extensively used as a marker for the differentiation of hematopoietic and neuronal cells, in addition to tissue and tumor stem cells.
