What is hydrazide of isonicotinic acid?
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What is hydrazide of isonicotinic acid?
Isoniazid is the hydrazide of isonicotinic acid. It is used to treat tuberculosis and HIV infection. Its therapeutic value results from its ability to block the synthesis of mycolic acids, which are components of the mycobacterial cell wall.
Which of the following drug is the derivative of isonicotinic acid?
Ethionamide, a derivative of isonicotinic acid, was first synthesized in 1956.
Which type of reaction occur in assay of isoniazid?
The FFC method involves the redox reaction of INH with ferric chloride, in the presence of potassium ferricyanide, under mild acidic conditions, to produce a blue colour with maximum absorption at 760 nm.
What is the name of indicator used in the assay of isonicotinic acid hydrazide?
Determination of Isonicotinic Acid Hydrazide Using N-Bromosuccinimide. In the present method Isoniazid (INH) has been determined volumetrically using N-bromosuccinimide. INH was taken in aqueous medium and titrated against standard N-bromosuccinimide using Bordeaux Red as indicator.
What type of chemical reaction is involved in the assay of isoniazid that is given in the British Pharmacopoeia?
redox reaction
The FFC method involves the redox reaction of INH with ferric chloride, in the presence of potassium ferricyanide, under mild acidic conditions, to produce a blue colour with maximum absorption at 760 nm.
What is the chemical composition of hydroxychloroquine?
C18H26ClN3OHydroxychloroquine / Formula
How does isoniazid inhibit mycolic acid synthesis?
Antimycobacterial drugs such as isoniazid; ethionamide and thiocarlide are inhibitors of mycolic acid synthesis inMycobacterium tuberculosis. Isoniazid in particular appears to block the formation of a Δ5−C24:1 fatty acid which could be a precursor of mycolic acids.
How is quinine synthesis?
1856: Sir William Henry Perkin attempts quinine synthesis by oxidation of N-allyltoluidine based on the erroneous idea that two equivalents of this compound with chemical formula C10H13N plus three equivalents of oxygen yield one equivalent of C20H24N2O2 (quinine’s chemical formula) and one equivalent of water.
What is the formula of chloroquine?
C18H26ClN3Chloroquine / Formula
What class of drug is hydroxychloroquine?
Hydroxychloroquine is in a class of drugs called antimalarials. It works by killing the organisms that cause malaria. Hydroxychloroquine may work to treat rheumatoid arthritis and systemic lupus erythematosus by decreasing the activity of the immune system.
What is mycolic acid synthesis?
Biosynthesis of mycolic acid precursors requires two types of fatty acid synthases (FASs), the eukaryotic-like multifunctional enzyme FAS I and the acyl carrier protein (ACP)-dependent FAS II systems, which consists of a series of discrete mono-functional proteins, each catalyzing one reaction in the pathway.
What is the ingredients in hydroxychloroquine?
PLAQUENIL (hydroxychloroquine sulfate) tablets contain 200 mg hydroxychloroquine sulfate, equivalent to 155 mg base, and are for oral administration. Inactive Ingredients: Dibasic Calcium Phosphate, Hydroxypropyl Methylcellulose, Magnesium Stearate, Polyethylene glycol 400, Polysorbate 80, Starch, Titanium Dioxide.
What is the purpose of mycolic acid in the mycobacterial cell wall?
tuberculosis cell walls contain fatty molecules known as mycolic acids, which make the bacteria less susceptible to antibiotics. These molecules also help the bacteria to subvert and then hide from the immune system.
