What is indole used for?
Table of Contents
What is indole used for?
Indole-3-carbinol is formed when these vegetables are cut, chewed or cooked. It can also be produced in the laboratory. People use indole-3-carbinol for cancer prevention, to treat systemic lupus erythematosus (SLE), and for many other conditions, but there is no good scientific evidence to support these uses.
What is indole Forte used for?
Indole Forté™ provides a spectrum of indole compounds to support estrogen balance, detoxification enzymes of the liver, and exert other cell-protective benefits in both men and women.
Which drug is indole derivative?
An antipsychotic used to treat schizophrenia. An atypical antipsychotic indicated in the treatment of schizophrenia….Indole Derivatives.
| Drug | Target | Type |
|---|---|---|
| Ziprasidone | Histamine H1 receptor | target |
| Ziprasidone | 5-hydroxytryptamine receptor 2A | target |
| Ziprasidone | Dopamine D4 receptor | target |
| Ziprasidone | 5-hydroxytryptamine receptor 7 | target |
Does indole-3-carbinol help with weight loss?
These findings suggest that I3C has a potential benefit in preventing obesity and metabolic disorders, and the action for I3C in vivo may involve multiple mechanisms including decreased adipogenesis and inflammation, along with activated thermogenesis.
Is indole toxic to humans?
High concentrations of indole are known to be toxic to cells due to perturbations in membrane potential.
Where is indole found?
indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter.
Does indole-3-carbinol increase testosterone?
According to our results, several steroid hormones (estradiol, estrone sulphate and androstenedione) were significantly increased in I3C treated tumor homogenates while testosterone was diminished. Interestingly, testosterone was significantly increased in the sera of I3C treated mice.
How do you make indole?
Indole can still be synthesized, however, using the Fischer indole synthesis by reacting phenylhydrazine with pyruvic acid followed by decarboxylation of the formed indole-2-carboxylic acid. This has also been accomplished in a one-pot synthesis using microwave irradiation.
Can indole-3-carbinol raise blood pressure?
Dietary administration of the aryl hydrocarbon indole-3-carbinol (I3C) at a dose of 0.15% induces a slowly developing form of ANG II-dependent hypertension, whereas dietary administration of a higher dose (0.3%) of I3C results in the development of ANG II-dependent malignant hypertension.
What is perfume indole?
Odour description: Pungent, floral, slightly naphtha and mothball like with a faecal and animalic musty character. An essential component of the scent of many flowers including jasmine, gardenia, narcissus and others it is it is very widely used and absolutely necessary for realistic flower scents.
Is indole-3-carbinol a estrogen blocker?
Indole-3-carbinol (I3C) selectively represses 17β-estradiol (E2)-activated estrogen receptor (ER)-a transcriptional activity in human cancer cells.
What indole smells like?
Indoles are a chemical compound that can either smell like jasmine (jasmine is naturally indolic) or like feces. They can also be created synthetically, so perfumers use them to intensify a floral fragrance. To some people, indoles smell like bad breath.
Does indole have a smell?
Indole is a solid at room temperature. It occurs naturally in human feces and has an intense fecal odor. At very low concentrations, however, it has a flowery smell, and is a constituent of many perfumes.
Is indole toxic?
What does indole do for bacteria?
Indole has recently been implicated as an important small molecule signal utilized by many bacteria to coordinate various forms of behavior. Indole plays a role in numerous bacterial processes, including: biofilm formation and maintenance, virulence factor production, antibiotic resistance and persister cell formation.
