What is lamellar Fibroplasia?

What is lamellar Fibroplasia?

Two histologic features of architectural disorder include: (A) concentric eosinophilic fibrosis (E), in which fibrosis encircles a rete peg; and (B) lamellar fibroplasia (L), in which the fibrosis is confined to the tip of the rete peg with stacks of collagen fibers.

What are Monomorphous melanocytes?

Cytologically, the monomorphous melanocytes of melanocytic nevi are in an erratic, unpredictable assortment of small and minimally larger sizes and shapes, e.g., round, oval, spindle-shaped, polygonal, plasmacytoid, ballooned, fusiform, dendritic, pagetoid and multinucleate.

What are Nevomelanocytes?

Congenital Melanocytic Nevi (CMN), on the other hand, are made up of pigment-producing cells called nevomelanocytes. These cells are not evenly distributed. When many nevomelanocytes are clumped together, they can result in moles on the skin because of the higher concentration of melanin (pigment).

What is a proliferation of melanocytes?

Atypical intraepidermal melanocytic proliferation (AIMP) is a descriptive histopathologic term commonly used in these cases to denote morphology sharing some features with melanoma but failing to meet criteria of a definitive benign or malignant diagnosis.

What is Pagetoid spread?

Pagetoid spread is defined as an individual cell proliferation in the upper levels of the epidermis, similar to the pattern of epidermal involvement by Paget’s disease of the breast.

Can nevus become cancerous?

A dysplastic nevus may develop into melanoma (a type of skin cancer), and the more dysplastic nevi a person has, the higher the risk of melanoma. A dysplastic nevus is sometimes called an atypical mole.

What is pagetoid scatter?

The pagetoid type is characterized by scattered individual or aggregates of large pleomorphic tumor cells with a vacuolated foamy cytoplasm and nuclei with dense chromatin within the epidermis or conjunctival epithelium. From: Encyclopedia of Cancer (Third Edition), 2019.

Why do nevi form?

Melanocytic nevi represent proliferations of melanocytes that are in contact with each other, forming small collections of cells known as nests. Melanocytic nevi commonly form during early childhood. Their onset is believed by some authorities to be, at least in part, a response to sun (ultraviolet) exposure.

How are proliferation and differentiation of melanocytes regulated?

Melanoblast/melanocyte proliferation and differentiation are regulated by the tissue environment, especially by keratinocytes, which synthesize endothelins, steel factor, hepatocyte growth factor, leukemia inhibitory factor and granulocyte-macrophage colony-stimulating factor.

What is pagetoid spread in melanoma?

Pagetoid melanocytosis is a histological pattern defined as ascent or upward scatter of single melanocytes or small groups of melanocytes, into suprabasal layers of the epidermis, including the granular layer and above.

What are Paget cells?

Mammary Paget cells are malignant epithelial cells derived from underlying ductal adenocarcinoma of the breast that invade into the skin of nipple and areolar areas. Toker cells are benign and may sometimes proliferate, resulting in a condition known as clear cell papulosis.

Is nevus benign or malignant?

A benign (not cancer) growth on the skin that is formed by a cluster of melanocytes (cells that make a substance called melanin, which gives color to skin and eyes). A nevus is usually dark and may be raised from the skin. Also called mole.

How do you remove nevus?

Is Removal Possible? Small nevi can be removed by simple surgical excision. The nevus is cut out, and the adjacent skin stitched together leaving a small scar. Removal of a large congenital nevus, however, requires replacement of the affected skin.

Are melanocytes precancerous?

Compared with other clinically apparent, benign, but potentially precancerous lesions, melanocytic nevi are unique as they arise relatively early in life.

What is pagetoid appearance?

Pagetoid dyskeratosis is defined as the presence of pale cells resembling those of Paget disease in the epidermis. Pagetoid cells have a similar pagetoid appearance and intraepidermal spread of epithelial, melanocytic, neuroendocrine, lymphoid, and histiocytic lineage.

What are Neurocutaneous markers?

Neurocutaneous syndromes are disorders that lead to growth of tumors in various parts of the body. They’re caused by the abnormal development of cells in an embryo and characterized by the tumors in various parts of the body (including the nervous system) and by certain differences in the skin.