What is the action of celecoxib?

What is the action of celecoxib?

The mechanism of action of celecoxib is due to selective inhibition of cyclooxygenase-2 (COX-2), which is responsible for prostaglandin synthesis, an integral part of the pain and inflammation pathway. [4] This pharmacologic activity gives celecoxib its analgesic, anti-inflammatory, and antipyretic effects.

What drug class is celecoxib?

Celecoxib is in a class of NSAIDs called COX-2 inhibitors. It works by stopping the body’s production of a substance that causes pain and inflammation.

How does ibuprofen interact with acyclovir?

Interactions between your drugs No interactions were found between acyclovir and ibuprofen. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

What is acyclovir target?

Acyclovir is a new antiviral drug that acts as a specific inhibitor of herpesvirus DNA polymerase. It shows good in vitro activity against herpes simplex and varicella-zoster viruses.

Is celecoxib an antipyretic?

Celecoxib is a nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgestic, and antipyretic properties. It is approved for the treatment of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and acute pain [1-3].

What is Celebrex used for?

Celecoxib is commonly known by the brand name Celebrex®. Celecoxib (Sell-e-COX-eb) is used to relieve some symptoms caused by arthritis, such as inflammation, swelling, stiffness, and joint pain.

What’s another name for celecoxib?

Celebrex is available as a generic drug called celecoxib. A generic drug is an exact copy of the active drug in a brand-name medication.

Can you take Celebrex with acyclovir?

Celecoxib may decrease the excretion rate of Acrivastine which could result in a higher serum level. The risk or severity of nephrotoxicity can be increased when Celecoxib is combined with Acyclovir.

What medicines interact with acyclovir?

Some products that may interact with this drug include: other drugs that may cause kidney problems (including nonsteroidal anti-inflammatory drugs-NSAIDs such as ibuprofen, naproxen). Acyclovir is very similar to valacyclovir. Do not use medications containing valacyclovir while using acyclovir.

How does acyclovir drug work?

Acyclovir is in a class of antiviral medications called synthetic nucleoside analogues. It works by stopping the spread of the herpes virus in the body. Acyclovir will not cure genital herpes and may not stop the spread of genital herpes to other people.

How does celecoxib inhibit COX-2?

How Celecoxib Works. As a COX-2 inhibitor, celecoxib blocks an inflammation-promoting enzyme called COX-2. Medications known as COX-2 inhibitors were developed to work as well as traditional NSAIDs but with fewer stomach problems.

Is celecoxib an antibiotic?

Drug repurposing was identified as one of the easy ways to find new antibiotics for emerging resistant bacteria (Brown, 2015). We have reported previously that celecoxib, a non-antibiotic agent in combination with an antibiotic (ampicillin) managed infection and inflammation caused due to S.

What is the side effect of celecoxib?

stomach pain, heartburn, gas, diarrhea, constipation, nausea, vomiting; swelling in your hands or feet; dizziness; or. cold symptoms such as stuffy nose, sneezing, sore throat.

What is Celebrex commonly used for?

Celecoxib is commonly known by the brand name Celebrex®. Celecoxib (Sell-e-COX-eb) is used to relieve some symptoms caused by arthritis, such as inflammation, swelling, stiffness, and joint pain. However, this medicine does not cure arthritis and will help you only as long as you continue to take it.

What is the mechanism of action for acyclovir?

Mechanism of Action: Acyclovir is converted to its triphosphate form, acyclovir triphosphate (ACV-TP), which competitively inhibits viral DNA polymerase, incorporates into and terminates the growing viral DNA chain, and inactivates the viral DNA polymerase.

What activates acyclovir?

Acyclovir, similar to all other nucleoside analogs, must be activated by addition of a phosphate group (phosphorylation) before it can inhibit the synthesis of viral DNA (HSV and VZV are DNA viruses).

What are contraindications of acyclovir?

The only absolute contraindication to acyclovir is hypersensitivity. Cautions include renal failure/impairment, immunocompromised host, potential risk of thrombotic thrombocytopenic purpura (TTP), and hemolytic uremic syndrome (HUS)).

What are the indications for acyclovir?

ZOVIRAX® (acyclovir) is indicated for the following conditions: The treatment of initial episodes of herpes genitalis. The suppression of unusually frequent recurrences of herpes genitalis (6 or more episodes per year). The acute treatment of herpes zoster (shingles) and varicella (chickenpox).

Which is the active form of acyclovir?

Aciclovir (ACV), also known as acyclovir, is an antiviral medication. It is primarily used for the treatment of herpes simplex virus infections, chickenpox, and shingles….Aciclovir.

Clinical data
CAS Number	59277-89-3
PubChem CID	2022
PubChem SID	46506002
IUPHAR/BPS	4829