What is the function of FGFR?
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What is the function of FGFR?
The fibroblast growth factor receptors (FGFRs) regulate important biological processes including cell proliferation and differentiation during development and tissue repair.
What does Fgfr stand for?
FGFR stands for fibroblast growth factor receptor. FGFR helps cells grow, survive, and multiply. In certain types of cancer, like in some cases of bladder cancer, the gene that controls FGFR can change or mutate (known as an FGFR alteration).
What are FGFR mutations?
FGFR3 gene mutations that lead to multiple myeloma and cervical cancer are thought to overactivate the FGFR3 protein in certain cells. The mutated receptor directs the cells to grow and divide in the absence of signals from outside the cell. This uncontrolled division can lead to the overgrowth of cancer cells.
What is FGFR amplification?
FGFR1 Amplification is an inclusion criterion in 1 clinical trial for esophageal squamous cell carcinoma, of which 1 is open and 0 are closed. Of the trial that contains FGFR1 Amplification and esophageal squamous cell carcinoma as inclusion criteria, 1 is phase 2 (1 open) [5]. Urethral Urothelial Carcinoma +
Is FGFR a tyrosine kinase?
Fibroblast growth factor receptors (FGFRs) are a family of receptor tyrosine kinases expressed on the cell membrane that play crucial roles in both developmental and adult cells.
How do you test FGFR?
An FDA-approved companion diagnostic test helps identify patients whose tumors have certain FGFR genetic alterations. The test detects certain clinically actionable FGFR genetic alterations from formalin-fixed paraffin-embedded urothelial tumor tissue.
What is Pan FGFR inhibitor?
FGFR, a family of receptor tyrosine kinases upregulated in many tumor cell types, plays a key role in cellular proliferation, cell survival and angiogenesis. Synonym: pan FGFR inhibitor LY2874455. pan fibroblast growth factor receptor inhibitor LY2874455.
How many FGFR are there?
The human fibroblast growth factor receptor (FGFR) family consists of four members: FGFR1 to FGFR4.
What is an FGFR inhibitor?
Fibroblast growth factor receptor (FGFR) inhibitors are drugs used for treating cancer that originates in the skin or in tissues that line or cover internal organs (carcinoma). FGFR is a receptor essential for the growth, differentiation, and maturation of a tumor cell.
Is FGFR an oncogene?
In summary, FGFR fusions occur frequently in a variety of human cancers and confer oncogenic properties to the cells that harbour these fusions.
What is FGFR fusion?
FGFR fusions can be classified into type I or type II fusions. In type I fusions, where the FGFR is the 3′ fusion partner, the extracellular and the transmembrane domains are excluded from the fusion protein, which includes only the FGFR kinase domain linked to the 5′ protein partner.
Is Erdafitinib FDA approved?
On April 12, 2019, the Food and Drug Administration granted accelerated approval to erdafitinib (BALVERSA, Janssen Pharmaceutical Companies) for patients with locally advanced or metastatic urothelial carcinoma, with susceptible FGFR3 or FGFR2 genetic alterations, that has progressed during or following platinum- …
What is azd4547?
An orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) with potential antineoplastic activity.
What is FGFR biomarker?
FGFR1 amplification is a genomic aberration recently identified in various types of cancer. Especially squamous cell carcinomas of the lung and the head and neck show this genetic alteration in high frequencies.
Who manufactures Erdafitinib?
Horsham, PA, April, 12 – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today that BALVERSA™ (erdafitinib) received accelerated approval from the U.S. Food and Drug Administration (FDA) for the treatment of adults with locally advanced or metastatic urothelial carcinoma (mUC) which has susceptible …
How effective is BALVERSA?
In the single-arm study of 87 bladder cancer patients who had undergone at least one prior chemotherapy treatment, Balversa elicited an overall response rate of 32.2%, including 2.3% complete responses, and it stalled tumor progression or death by a median of 5.4 months.
What is FGFR inhibitor?
What is the mechanism of action of dovitinib?
Dovitinib binds to and inhibits the phosphorylation of type III-V RTKs, such as vascular endothelial growth factor receptor (VEGFR) and platelet-derived growth factor receptor (PDGFR) that promote tumor cell proliferation and survival in certain cancer cells.
Does dovitinib have antitumor activity in pancreatic cancer?
Objectives: Preclinical studies demonstrated antitumor activity of dovitinib in pancreatic cancer models.
What is a non-selective FGFR inhibitor?
The nonselective FGFR TKIs target other RTKs such as vascular endothelial growth factor receptors (VEGFRs) and platelet-derived growth factor receptors (PDGFRs), and usually present modest bioactivity against the FGFR family. Most of the RTKIs assessed to date are non-selective FGFR inhibitors.
Is there a clinical trial for FGFR inhibition?
Bladder, Lung, and Gastric cancers all are areas of interest in advanced clinical trials testing FGFR pathway inhibition. There exist a wide scope of histologies where FGFR inhibition may be of clinical benefit, many phase II trials are currently in the recruiting stages or are actively ongoing. FGFR MUTATION
