What is the N-Myc gene?
Table of Contents
What is the N-Myc gene?
MYCN (MYCN Proto-Oncogene, BHLH Transcription Factor) is a Protein Coding gene. Diseases associated with MYCN include Feingold Syndrome 1 and Familial Retinoblastoma. Among its related pathways are Signaling by Receptor Tyrosine Kinases and Development of ureteric collection system.
What does Myc do in the cell?
MYC gene encodes a multifunctional, nuclear phosphoprotein that controls a variety of cellular functions, including cell cycle, cell growth, apoptosis, cellular metabolism and biosynthesis, adhesion, and mitochondrial biogenesis.
Where is the Myc gene located?
chromosome 8
The results indicate that the human c-myc gene is located on chromosome 8. The analysis of hybrids between rodent cells and human Burkitt lymphoma cells, which carry a reciprocal translocation between chromosomes 8 and 14, allowed the mapping of the human c-myc gene on region (q24 leads to qter) of chromosome 8.
What is the difference between Myc and c-Myc?
Myc and c-myc are the same thing, the normal cellular (hence the c) version of this protein, which can be oncogenic when mutated. The myc tag is a 10-residue sequence derived from c-myc, which is a much larger protein.
What is N-Myc amplification?
A laboratory test in which cells in a sample of tumor tissue or bone marrow are checked to see how many copies of the MYCN gene are in the tumor DNA. MYCN is important for cell growth. Having more than 10 copies of the gene is called MYCN gene amplification.
What chromosome is MYCN on?
chromosome 2
(1994) used fluorescence in situ hybridization in the study of 5 human neuroblastoma cell lines to demonstrate that, in addition to amplified MYCN in HSRs or double minutes, single-copy MYCN was present at the normal position on chromosome 2.
How is MYC activated?
Later, MYC was illustrated to be activated through chromosomal translocation in Burkitt lymphoma (see Conacci-Sorrell et al. 2014). MYC is also commonly activated in tumorigenesis as a consequence of both oncogenic and epigenetic events (Boxer and Dang 2001; Eilers and Eisenman 2008; Dang 2012).
What genes does Myc regulate?
Myc regulates its downstream target genes by binding to cis-acting DNA motifs called E-boxes. The canonical E-box sequences CACGTG and CATGTG [23] as well as non-canonical E-boxes, such as CATGCG, CACGCG, CACGAG, and CAACGTG have been identified as cis-acting elements bound by Myc [43].
How does Myc gene work?
The c-Myc gene serves as a “master regulator” of cellular metabolism and proliferation. Since it is activated by a large number of oncogenic pathways and, in turn, stimulates many of the metabolic changes that result in malignant transformation, it is truly “both the chicken and the egg”.
How many forms of Myc are there?
C-Myc. The myc family includes four transcription factors, c-myc, N-myc, L-myc, and S-myc, involved in the control of cell growth, differentiation, and apoptosis (69).
How many amino acids are present in the MYC protein?
The gene encodes for a major 439 amino acid, 64 kDa c-Myc protein.
Where is the Philadelphia chromosome found?
Philadelphia chromosome. A piece of chromosome 9 and a piece of chromosome 22 break off and trade places. The BCR-ABL gene is formed on chromosome 22 where the piece of chromosome 9 attaches. The changed chromosome 22 is called the Philadelphia chromosome.
What is N-Myc in neuroblastoma?
N-Myc amplification is a crucial prognostic factor in neuroblastoma, which is associated with almost all features related with poor prognosis and a higher probability of unfavourable outcome.
Is MYC an essential gene?
Myc is an essential gene having multiple functions such as in cell growth, differentiation, apoptosis, genomic stability, angiogenesis, and disease biology.
How does Myc promote cell proliferation?
MYC stimulates cell-cycle progression and the cellular proliferation through the regulation of genes related to cell-cycle control. MYC induces positive cell-cycle regulators such as several cyclins, CDKs and E2F transcription factors (green arrows).
How is Myc activated?
Is MYC a gene?
MYC (MYC Proto-Oncogene, BHLH Transcription Factor) is a Protein Coding gene. Diseases associated with MYC include Burkitt Lymphoma and High-Grade B-Cell Lymphoma Double-Hit/Triple-Hit.
