What is the use of piperazine?
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What is the use of piperazine?
Piperazine belongs to the family of medicines called anthelmintics. Anthelmintics are used in the treatment of worm infections. Piperazine is used to treat: common roundworms (ascariasis) and.
Which is example of piperazine derivative?
The piperazine derivatives include 1-benzylpiperazine (BZP), 1,3-trifluoromethylphenylpiperazine (TFMPP), 1-(3-chlorophenyl) piperazine (mCPP) and 1-(4-methoxyphenyl) piperazine (MeOPP); a full summary of their chemical properties is presented in the ‘Physical Descriptions’ section.
Which drug is of piperazine class?
Organic compoundPiperazine / ClassificationIn chemistry, organic compounds are generally any chemical compounds that contain carbon-hydrogen or carbon-carbon bonds. Due to carbon’s ability to catenate, millions of organic compounds are known. Wikipedia
What is the nature of piperazine?
Piperazine (/paɪˈpɛrəziːn/) is an organic compound that consists of a six-membered ring containing two nitrogen atoms at opposite positions in the ring. Piperazine exists as small alkaline deliquescent crystals with a saline taste.
What is piperazine adipate?
Piperazine adipate is a broad spectrum anthelmintic agent that inhibits malate oxidation in Ascaridia galli and Heterakis gallinae. CAS No. 142-88-1.
What is the side effect of piperazine?
Side-effects include gastrointestinal disturbances, headache, dizziness and urticaria. Seizures occur rarely, and piperazine is contraindicated in patients who have a history of a seizure disorder. Piperazine and pyrantel pamoate are antagonistic and should not be co-administered.
What is the brand name of piperazine?
Piperazine Citrate (GSK) (500mg) Manufacturer: Glaxo SmithKline Pharmaceuticals Ltd.
What is piperazine citrate?
Piperazine Citrate Syrup is an anti-helminitic medication. It is used in the treatment of worm infections. It works by killing the worms that cause infection.
Which drug contain piperazine ring?
Piperazine is a very popular motif in CNS drugs as shown in three atypical antipsychotics, one antidepressant, and one sedative hypnotic. Piperazine is also embedded in two tyrosine kinase inhibitors: imatinib (Gleevec™) and dasatinib (Sprycel™).
What is the mechanism of action of piperazine?
Mechanism of action Piperazine acts as a γ-aminobutyric acid (GABA) agonist, causing chloride channel opening, neural hyperpolarization and flaccid paralysis of susceptible parasites.
How do you use piperazine syrup?
Piperazine Citrate Syrup should be used in the dose and duration as advised by your doctor. It should be taken with food, preferably at a fixed time. Avoid skipping any doses and finish the full course of treatment even if you feel better. Do not take a double dose to make up for a missed dose.
Can humans take piperazine?
Adults and children—Dose is based on body weight and must be determined by your doctor. However, the usual dose is 65 mg (piperazine hexahydrate) per kilogram (29.5 mg per pound) of body weight per day for seven days in a row. Treatment may need to be repeated in one week.
How do you take piperazine?
Dosing
- Adults and teenagers—1.8 grams every four hours for a total of three doses in one day. Treatment may need to be repeated in two weeks.
- Children—Dose is based on age. Treatment may need to be repeated in two weeks. Up to 2 years of age: 600 milligrams (mg) every four hours for a total of three doses in one day.
Is piperazine the same as ivermectin?
However, piperazine citrate administration showed better level of T4 hormone in infested birds (commercial and rural) as compared to Ivermectin. This might be due to better anthelmintic ability of piperazine citrate against nematodes as compared to ivermectin.
What is the role of piperazine in drug design and development?
Piperazine and its derivatives offers a wide range of biological activities including antimicrobial, antiviral, antimalarial, antituberculosis and anticancer activity [36] .
What is the mechanism of action of piperazine citrate elixir?
How Piperazine Citrate Elixir works. Piperazine belongs to class of drugs called anthelmintic. It works by paralyzing the worms and making them to pass in the stool. It is effective against the intestinal nematodes roundworm (Ascaris lumbricoides), pinworm and threadworm (Enterobius vermicularis).
What is the difference between syrup and elixir?
Syrup is concentrated, viscous, aqueous solution of sugar or a sugar substitute with or without flavor and medical substance. 01. Elixirs are clear, pleasantly flavored, sweetened hydro alcoholic liquids intended for oral use.
What are the 4 usual components of syrups?
Most syrup contains the following components in addition to the purified water and any medicinal agents present: (a) The sugar, usually sucrose, or sugar substitute used to provide sweetness and viscosity; (b) Antimicrobial preservatives; (c) Flavorants; and (d) Colorants.
What are the types of elixirs?
Types
- aromatic elixirs (USP)
- isoalcoholic elixirs (NF)
- compound benzaldehyde elixirs (NF)
