Can a giant cell tumor turn cancerous?
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Can a giant cell tumor turn cancerous?
Background: Primary and recurrent giant cell tumor of bone is typically benign; however, rarely giant cell tumor of bone can undergo malignant transformation.
How rare is a giant cell tumor?
Giant cell tumors usually occur in young adults, and are slightly more common in females. They are quite rare, occurring in only about one out of every one million people per year. Although giant cell tumors are not cancerous, they are aggressive and can destroy the surrounding bone.
Is giant cell tumor fatal?
Giant Cell tumors (GCT) are benign tumors with potential for aggressive behavior and capacity to metastasize. Although rarely lethal, benign bone tumors may be associated with a substantial disturbance of the local bony architecture that can be particularly troublesome in peri-articular locations.
What percentage of giant cell tumor is malignant?
We identified 4 large series of patients with malignant giant cell tumor of bone that provided data on 2315 patients with giant cell tumor of bone. Across these studies, the cumulative incidence of malignancy was 4.0%; the cumulative incidence of primary malignancy was 1.6% compared with 2.4% for secondary malignancy.
How quickly do giant cell tumors grow?
Giant cell tumor of bone (GCTB) in skeletally immature patients is rare, and little is known regarding how fast GCTB can grow. We report a case of a 10-year-old skeletally immature girl with pathologically proven GCTB with obvious growth plate invasion that showed surprisingly rapid growth over only 14 days.
What is the prognosis of giant cell tumor?
A review of the world literature1,2,6,7,39,40 revealed an 80% to 85% survival rate in patients with pulmonary metastases from giant cell tumor of the bone. In fact, spontaneous regression of pulmonary lesions has been reported in the literature.
How fast does giant cell tumor grow?
How often do giant cell tumors come back?
For most cases, the postoperative recurrence could be observed within 24 months after the surgery. Depending on the type of surgical procedure and local presentation of the tumor, the recurrence rate of GCTB could range from 2.5% to 45% [5], [6].
What is a giant cell tumor on finger?
What is a giant cell tumor? Giant cell tumor of bone is a rare, aggressive non-cancerous tumor. It generally happens in adults between ages 20 and 40 when skeletal bone growth is complete. It usually develops near a joint at the end of the bone.
