How is carboplatin dosed?
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How is carboplatin dosed?
Carboplatin Dose (mg) = Target area under the curve (AUC mg/mL/min) x (GFR* + 25) *GFR estimated by calculated creatinine clearance using Cockcroft-Gault Equation (see below).
Can obese people have chemotherapy?
Despite the difficulties of reporting toxicities in clinical trials, multiple studies show that obese women treated with chemotherapy based on actual body weight do not experience more short-term or long-term toxicities compared with normal/healthy weight individuals [11,41–48].
Which drugs are dosed by ideal body weight?
Dosing Weights
| Drug Name | Adjustment in Obesity |
|---|---|
| Daptomycin | Adjusted Body Weight when patient weight >120% of ideal body weight Total Body Weight when <=120% of ideal body weight |
| Ethambutol | Ideal Body Weight when patient weight >120% of ideal body weight |
How much carboplatin can you have?
You might have carboplatin every 3 to 4 weeks. Each 3 or 4 week period is a cycle of treatment. You might have between 4 to 6 cycles. How often you have it depends on your type of cancer.
What cancers are associated with obesity?
Overweight/obesity is known to increase the risk of at least 13 different types of cancer: post-menopausal breast cancer, colorectal cancer, kidney (renal cell) cancer, endometrial cancer, thyroid cancer, pancreatic cancer, multiple myeloma, liver cancer, ovarian cancer, adenocarcinoma of the esophagus, gastric cardia …
How do you help a morbidly obese person?
Here’s how:
- Wait for cues. Your friend or loved one may not yet be ready to make the lifestyle changes necessary to lose weight in healthy ways.
- Emphasize good health, if anything.
- Encourage healthy eating.
- Be an exercise buddy.
- Share useful information.
- Keep them motivated.
- Help reduce their stress.
- No judgment.
What is the nadir for carboplatin?
The nadir usually occurs about day 21 in patients receiving single-agent therapy. By day 28, 90% of patients have platelet counts above 100,000/mm³; 74% have neutrophil counts above 2,000/mm³; 67% have leukocyte counts above 4,000/mm³.
How fast can you run carboplatin?
Carboplatin Injection is usually administered by an infusion lasting 15 minutes or longer.
Why do obese patients get worse care?
The doctors “reported that seeing patients was a greater waste of their time the heavier that they were, that physicians would like their jobs less as their patients increased in size, that heavier patients were viewed to be more annoying, and that physicians felt less patience the heavier the patient was,” the …
How does weight affect drug dosing?
As clearance determines a drug’s maintenance dose, clinicians should consider how lean body weight, rather than total body weight, impacts dosing. When lean body weight increases there will be a corresponding increase in drug clearance and an increased dose may be required.
