Is gentamicin compatible with clindamycin?
Table of Contents
Is gentamicin compatible with clindamycin?
The combination of clindamycin phosphate 900 mg, gentamicin sulfate 80 mg, and cefazolin sodium 1 g in D5W 100 ml was found to be compatible for up to 4 hours.
Are clindamycin and gentamicin synergistic?
In addition, the combination of gentamicin and clindamycin is synergistic, except for the combination of 0.1 mM gentamicin with 0.25 mM clindamycin. As the results of this study demonstrate, neuromuscular blocking effects may be induced even at commonly used doses because of the synergistic interactions.
What coverage does clindamycin provide?
With its excellent activity against both Gram-positive cocci and Gram-positive or -negative anaerobes, clindamycin has a role in the treatment of head and neck, respiratory, bone and soft tissue, abdominal, and pelvic infections (1–4).
What bacteria does gentamicin cover?
Gentamicin and other aminoglycosides are typically used in combination with a penicillin or cephalosporin for treatment of severe infections with E. coli, Staphylococcus aureus, Enterobacter, Klebsiella, Serratia, Pseudomonas aeruginosa, and other gram negative bacteria resistant to less toxic antibiotics.
Is clindamycin compatible with LR?
6, 9 and 12 mg/mL (equivalent to clindamycin base) in dextrose injection 5%, sodium chloride injection 0.9%, or Lactated Ringers Injection in glass bottles or minibags, demonstrated physical and chemical stability for at least 16 days at 25°C….
| Dose | Diluent | Time |
|---|---|---|
| 900 mg | 50-100 mL | 30 min |
| 1200 mg | 100 mL | 40 min |
What drugs interact with gentamicin?
Some affected drugs include: amikacin, tobramycin, amphotericin B, cidofovir, cisplatin, polymyxin B, cephalosporins such as cephaloridine, nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, among others.
Does clindamycin treat Pseudomonas aeruginosa?
Responses of Pseudomonas aeruginosa to antimicrobials. Frontiers in Microbiology. 2013….A Study List For Pharmacy Students: Antibiotics That Can Cover Pseudomonas and/or MRSA.
| Pseudomonas | MRSA | |
|---|---|---|
| Clindamycin | – | + |
| Vancomycin | – | + |
| Daptomycin | – | + |
| Telavancin | – | + |
Which antibiotics were most effective against S aureus against MRSA?
The most effective antibiotics for MRSA eradication are vancomycin, linezolid, and a few others in combination with vancomycin (Figure 2). Daptomycin, clindamycin, doxycycline, tigecyclin, and trimethoprim–sulfamethoxazole combo are also efficient against most MRSA strains (Deresinski, 2005).
Does clindamycin cover Pseudomonas?
In addition aminoglycosides and fluoroquinolones are indicated as a “no” for MRSA, but they may be an option as part of combination therapy….A Study List For Pharmacy Students: Antibiotics That Can Cover Pseudomonas and/or MRSA.
| Pseudomonas | MRSA | |
|---|---|---|
| Sulfamethoxazole-trimethoprim | – | + |
| Clindamycin | – | + |
| Vancomycin | – | + |
Is clindamycin a broad spectrum antibiotic?
Introduction. Clindamycin is a broad spectrum antibiotic used orally, topically and parenterally for bacterial infections due to sensitive organisms. Clindamycin has been linked to rare instances of acute liver injury.
Does gentamicin Cover Staph aureus?
Sixteen infections caused by Staphylococcus aureus and six infections caused by S albus were treated with gentamicin sulfate. The antibiotic was effective in eradicating the S aureus infections in all but two patients.
What is not compatible with LR?
Eight drugs, ciprofloxacin, cyclosporine, diazepam, ketamine, lorazepam, nitroglycerin, phenytoin, and propofol, were found to be incompatible and should not be administered with LR.
What antibiotics are compatible with lactated Ringer’s?
Ampicillin, cefepime, hydrocortisone, and levofloxacin were also physically compatible with Lactated Ringers.
Which drug should not be used with gentamicin?
Avoid potent diuretics (e.g., ethacrynic acid, furosemide) because they increase the risk of ototoxicity; when administered intravenously, diuretics may enhance aminoglycoside toxicity by altering antibiotic concentrations in serum and tissue. This medication contains gentamicin.
Which antibiotic is best for Pseudomonas aeruginosa?
At present, the use of newer penicillins, piperacillin, azlocillin, or selected antipseudomonal cephalosporins, in combination with amikacin or tobramycin, appears to be the preferable antimicrobial therapy for serious P. aeruginosa infections.
Does clindamycin Cover staph aureus?
The results suggest that clindamycin might still be useful as a second-line agent for infections caused by S. aureus and S. epidermidis, although its activity against MRSA was limited to approximately two-thirds of the MRSA strains tested in this study.
Does clindamycin cover MRSA?
Treatment includes incision and drainage, with the addition of antibiotics if the abscess is large or there is surrounding cellulitis, incomplete drainage, or fever [1] Oral antibiotics effective against ca-MRSA usually include septra, doxycycline, and clindamycin.
What antibiotics cover Pseudomonas aeruginosa?
Pseudomonas infection can be treated with a combination of an antipseudomonal beta-lactam (eg, penicillin or cephalosporin) and an aminoglycoside. Carbapenems (eg, imipenem, meropenem) with antipseudomonal quinolones may be used in conjunction with an aminoglycoside.
