What is a brain transcriptome?

What is a brain transcriptome?

Methods of Transcriptome Analysis of the Brain. Most methods of brain transcriptome analysis involve identifying differentially expressed genes, either among normal tissues of various brain regions, or between normal tissues and disease tissues such as autism or schizophrenia.

Which techniques are used to obtain transcriptome data?

Two biological techniques are used to study the transcriptome, namely DNA microarray, a hybridization-based technique and RNA-seq, a sequence-based approach. RNA-seq is the preferred method and has been the dominant transcriptomics technique since the 2010s.

What is transcriptomic data?

Transcriptomic Data Analysis involves characterization of all transcriptional activity (coding and non-coding), or a select subset of RNA transcripts within a given sample. The analysis of transcriptomes allows the identification of candidate genes and expressed markers associated with traits of interest.

What is transcriptome analysis used for?

Transcriptome Analysis is most commonly used to compare specific pairs of samples. The differences may be due to different external environmental conditions, e.g., hormonal effects or toxins. More commonly, healthy and disease states are compared.

What are neuronal subtypes?

There are two broad classes of cortical neurons: interneurons, which make local connections; and projection neurons, which extend axons to distant intracortical, subcortical and subcerebral targets.

Which of the following is a widely used method for transcriptome analysis?

Microarrays have been used widely to study the transcriptomes because they provide a cost-effective means of assessing and comparing mRNA levels for thousands of genes at once.

What is a Purkinje neuron?

Purkinje cells, also called Purkinje neurons, are neurons in vertebrate animals located in the cerebellar cortex of the brain. Purkinje cell bodies are shaped like a flask and have many threadlike extensions called dendrites, which receive impulses from other neurons called granule cells.

Do brain cells make you smarter?

What makes some people smarter than others? It could come down to your individual brain cells – the bigger and faster your neurons, the higher your IQ. If confirmed, the finding could lead to new ways to enhance human intelligence.

What is basket cell?

Basket cells are multipolar GABAergic interneurons that function to make inhibitory synapses and control the overall potentials of target cells. In general, dendrites of basket cells are free branching, contain smooth spines, and extend from 3 to 9 mm.