What is hydrotropic method?

What is hydrotropic method?

Hydrotropic solubilization is a technique used to increase the aqueous solubility of poorly water-soluble drugs and the present study was aimed at developing a hydrotropic technique to increase the solubility of lornoxicam, using 2 M sodium benzoate as the hydrotropic agent.

What is meant by hydrotropic agents?

Hydrotropic agents, according to the definition first put forward by Neuberg. (1916), are metal salts of organic acids which at fairly high concentrations, consider- ably increase the aqueous solubility of organic substances normally slightly soluble. in water.

How does Hydrotropy happen?

Hydrotropy is an organic solvent-free solubilizing approach. It is basically a molecular phenomenon occurring by blending poorly soluble solutes with the large amount of hydrotrope resulting in an enhancement of the aqueous solubility of poorly soluble solute (Kim et al., 2010).

Is sodium benzoate a Solubilizer?

On the other hand, the hydrotropic salts, sodium benzoate, sodium salicylate, and sodium gentisate, are shown to be the best water solubilizers in 1-butanol. Sodium salicylate showed the maximum solubilizing power.

What do you mean by solubilization?

Solubilization is the action of certain chemical reagents on organic materials (such as animal or plant tissue) that effects a structural breakdown (or digestion) into a liquid form that can then be directly dissolved in a liquid scintillation cocktail.

What is co solvency?

Cosolvents are defined as water-miscible organic solvents that are used in liquid drug formulations to increase the solubility of poorly water-soluble substances or to enhance the chemical stability of a drug.

What is sodium xylene sulfonate used for?

Definition. Sodium xylene sulfonate is a wetting agent that can also be found in hair care products and cleansers. We use it in our products to help a formula spread across a surface, making cleaning more efficient.

Is sodium benzoate a Hydrotrope?

Hydrotropic solubilization is one of them. In the present study, sodium benzoate was chosen as hydrotrope to enhance the solubility of Lornoxicam for its spectrophotometric estimation in their marketed formulation.

What is solubilization in microbiology?

Other mechanisms of mineral phosphate solubilization by microorganisms are the production of inorganic acids (such as sulphuric, nitric, and carbonic acids) and the production of chelating substances.

Is a an example of cosolvent?

Cosolvents that are most used are methanol, ethanol and water. The effectiveness of a cosolvent is determined by its solubilization power. This is the maximum rate of dissolution of a solute in mixtures of various compositions.

What is co solvent and example?

Definition of cosolvent : a solvent that in conjunction with another solvent can dissolve a solute ether and alcohol are cosolvents for pyroxylin.

Is sodium xylene sulfonate a surfactant?

Sodium xylenesulfonate is a member of the class of surfactants called hydrotropes. As used in liquid detergent formulations, it stabilizes aqueous solutions containing both organic surfactants and inorganic salts such as phosphates, which could otherwise be incompatible.

What is SXS chemical?

STEPANATE SXS is an anionic surfactant used in liquid detergent, heavy-duty cleaning, wax stripping, dishwashing detergent formulations, and textile applications. It functions as a solubilizer, coupling agent, and cloud point depressant.

Is urea a hydrotrope?

Urea is widely used as a hydrotropic agent, as it was shown to enhance the aqueous solubility of many lipophilic drugs including diclofenac (250-fold), hydrochlorothiazide (74-fold), and many others (Coffman and Kildsig, 1996a,b).

What is sodium cumene sulfonate?

SODIUM CUMENE SULFONATE is an anionic surfactant used in liquid and powdered detergent formulation, heavy duty cleaners, wax strippers and dishwashing detergents. SODIUM CUMENE SULFONATE functions as a solubilizing agent, coupling agent and cloud point depressant.

What is solubilization and example?

A Solubilization Solubilization is the action of certain chemical reagents on organic materials (such as animal or plant tissue) that affects a structural breakdown (or digestion) into a liquid form that can then be directly dissolved in a liquid scintillation cocktail.

What is meant by solubilization?

solubilise. / (ˈsɒljʊbɪˌlaɪz) / verb. to make or become soluble, as in the addition of detergents to fats to make them dissolve in water.

What is solubilization simple?

What is solubilization of inorganic phosphorus?

Phosphate solubilizing microbes (PSMs) are a group of beneficial microorganisms capable of hydrolyzing organic and inorganic insoluble phosphorus compounds to soluble P form that can easily be assimilated by plants.