What is meant by platelet function test?

What is meant by platelet function test?

A platelet count test measures the number of platelets in your blood. A lower than normal platelet count is called thrombocytopenia. This condition can cause you to bleed too much after a cut or other injury that causes bleeding. A higher than normal platelet count is called thrombocytosis.

What is the best test for platelet function?

Light transmission platelet aggregometry on platelet-rich plasma. LTA, designed by Born in the 1960s, is performed by using the PRP as milieu. It is still deemed the gold standard test for the assessment of the various platelet functions.

How do you test for platelet function disorder?

Laboratory testing for these disorders involves CBC with platelet count and peripheral blood smear, basic coagulation tests, and tests to rule out VWD; further testing may include platelet aggregation tests, platelet flow cytometry, and in some cases, genetic testing.

What is a P2Y12 platelet function test?

Test results are in P2Y12 reaction units (PRU). This test measures the extent of platelet aggregation in the presence of P2Y12 inhibitor drugs such as clopidogrel (Plavix), prasugrel (Effient), ticagrelor (Brilinta) and ticlopidine (Ticlid).

What medications affect platelet function?

Drugs. Aspirin, other NSAIDs, inhibitors of the platelet P2Y12 adenosine diphosphate (ADP) receptor (eg, clopidogrel, prasugrel, ticagrelor), and glycoprotein IIb/IIIa receptor inhibitors (eg, abciximab, eptifibatide, tirofiban) may induce platelet dysfunction.

What is a normal P2Y12?

reference range: 180 – 376 PRU. Values less than 180 PRU may be evidence of a P2Y12 inhibitor effect.

What is P2Y12 platelet?

The P2Y12 receptor is a G-inhibitory-protein receptor in the platelet membrane, which is activated by ADP and results in the inhibition of adenylyl cyclase, thereby inducing platelet aggregation [33,34]. Moreover, the activation of P2Y12 receptor hinders the antiplatelet effects of prostacyclin.

How is platelet function disorder treated?

Medication to help strengthen the blood’s ability to clot during and after surgery. Medications to help stabilize clots that form during surgery. Iron supplements. Platelet transfusions, which may be needed for people having major surgery or those with a severe platelet function disorder.

What is P2Y12 test?

Impedance. Clinical Information. Test results are in P2Y12 reaction units (PRU). This test measures the extent of platelet aggregation in the presence of P2Y12 inhibitor drugs such as clopidogrel (Plavix), prasugrel (Effient), ticagrelor (Brilinta) and ticlopidine (Ticlid).

What does a low P2Y12 mean?

Values less than 180 PRU may be evidence of a P2Y12 inhibitor effect. Platelet counts less than 119K or more than 502K, and Hematocrit values less than 33% or greater than 52% can interfere with testing and valid results may not be obtained.

What are the names of antiplatelet drugs?

Antiplatelets include:

• ASA, also called acetylsalicylic acid (Aspirin, Asaphen, Entrophen, Novasen)
• Clopidogrel (Plavix)
• Prasugrel (Effient)
• Ticagrelor (Brilinta)

Can Chicken increase platelets?

Lean meats such as fish, chicken and turkey are rich in protein, zinc and Vitamin B12, all of which help increase the blood platelet count.

Can low platelets cause death?

If your platelet count is extremely low, you could start bleeding internally all by itself. If untreated, a very low platelet count could be fatal.