What is urothelial carcinoma in situ?

What is urothelial carcinoma in situ?

Urothelial carcinoma in situ (CIS) is a high-grade noninvasive malignancy with a high tendency of progression. Although it is typically grouped with other nonmuscle invasive bladder cancers, its higher grade and aggressiveness make it a unique clinical entity.

What is in situ carcinoma in pathology?

A group of abnormal cells that remain in the place where they first formed. They have not spread. These abnormal cells may become cancer and spread into nearby normal tissue.

How is urothelial carcinoma detected?

A sample of your urine is analyzed under a microscope to check for cancer cells in a procedure called urine cytology. Imaging tests. Imaging tests, such as computerized tomography (CT) urogram or retrograde pyelogram, allow your doctor to examine the structures of your urinary tract.

What is the treatment for carcinoma in situ in the bladder?

The BCG drug is inserted into the bladder through a catheter. The therapy triggers the immune system to attack bladder cancer cells. It is one of the most effective treatments for bladder cancer, especially carcinoma in situ (CIS).

Is carcinoma in situ considered malignant?

Carcinoma in situ refers to cancer in which abnormal cells have not spread beyond where they first formed. The words “in situ” mean “in its original place.” These in situ cells are not malignant, or cancerous. However, they can sometime become cancerous and spread to other nearby locations.

How accurate is a urine cytology test?

Urinary cytology is most helpful in diagnosing invasive high-grade (the cancer cells grow and spread quickly) tumors and carcinoma in situ (a group of abnormal cells that are found only in the place where they first formed in the body). It has a 95% accuracy rate for diagnosing these two conditions.

What is a positive urine cytology?

The urine cells were abnormal and might be cancerous. Positive. A positive result indicates that cancer cells were found in your urine.

Is urothelial carcinoma the same as bladder cancer?

Urothelial carcinoma, also known as transitional cell carcinoma (TCC), is by far the most common type of bladder cancer. In fact, if you have bladder cancer it’s almost certain to be a urothelial carcinoma. These cancers start in the urothelial cells that line the inside of the bladder.

Is carcinoma in situ of bladder curable?

The outlook for people with stage 0a (non-invasive papillary) bladder cancer is very good. These cancers can be cured with treatment. During long-term follow-up care, more superficial cancers are often found in the bladder or in other parts of the urinary system.

Can carcinoma in situ be cured?

About 1 in 5 new breast cancers will be ductal carcinoma in situ (DCIS). Nearly all women with this early stage of breast cancer can be cured. DCIS is also called intraductal carcinoma or stage 0 breast cancer. DCIS is a non-invasive or pre-invasive breast cancer.

What is the treatment for carcinoma in situ?

TREATMENT APPROACH Patients with DCIS undergo local treatment with breast-conserving therapy (BCT) or mastectomy. BCT consists of lumpectomy (also called breast-conserving surgery, wide excision, or partial mastectomy) followed in most cases by adjuvant radiation.

Is carcinoma in situ reversible?

Unlike mild or moderate dysplasia in which similar changes are seen but which involve only a portion of the thickness or depth of epithelium, carcinoma in-situ is not reversible with the elimination of the causative agent such as cigarette smoke, and eventually is expected to become invasive carcinoma.

Is in situ the same as benign?

Tumor Terminology Generalizations In addition to benign tumors, there are in situ tumors and invasive tumors. In situ tumors do not invade the basement membrane, whereas invasive tumors do invade the basement membrane.

Is cytology are more accurate than biopsy?

Like many types of medical tests, a cytology test can give a false negative or false positive result. Additionally, in some cases, tissue biopsies can be more accurate than cytology tests.

Is urothelial carcinoma slow growing?

Papillary urothelial carcinoma is often slow growing , and it can be easier to treat than other types of bladder cancer. The prognosis is generally good. A person who receives a diagnosis of bladder cancer in the earliest stage, before it has started to spread, has a 95% chance of living for at least another 5 years.