What medications should not be taken when eating grapefruit?
Table of Contents
What medications should not be taken when eating grapefruit?
Some statin drugs to lower cholesterol, such as Zocor (simvastatin) and Lipitor (atorvastatin). Some drugs that treat high blood pressure, such as Procardia and Adalat CC (both nifedipine). Some organ-transplant rejection drugs, such as Neoral and Sandimmune capsule or oral solution (both cyclosporine).
Is grapefruit juice a cyp450 inhibitor?
Grapefruit juice is associated with the inhibition of Cytochrome P450 enzyme system, particularly the CYP3A4 enzyme7.
What is the consequence of taking grapefruit juice on the effect of a prodrug?
Conversely, if the medication is a prodrug, it needs to be metabolised to be converted to the active drug. Compromising its metabolism lowers concentrations of the active drug, reducing its therapeutic effect, and risking therapeutic failure.
Why can’t you eat grapefruit with some medications?
Grapefruit interferes with proteins in the small intestine and liver that normally break down many medications. Eating grapefruit or drinking grapefruit juice while taking these medications can lead to higher levels of them in your blood — and more side effects.
Does grapefruit interact with any medications?
Yes. Grapefruit and certain other citrus fruits, such as Seville oranges, can interfere with several kinds of prescription medications. Don’t take these interactions lightly. Some can cause potentially dangerous health problems.
Is grapefruit a strong CYP3A4 inhibitor?
Scientific studies indicate that grapefruit and grapefruit juice inhibit CYP3A4, which metabolizes more than 65% of all drugs, as well as P-glycoprotein (P-gp) and a number of other metabolic enzymes and transporters.
How long does it take to metabolize grapefruit?
The interaction potential of even high amounts of grapefruit juice with CYP3A4 substrates dissipates within 3 to 7 days after ingestion of the last dose of grapefruit juice.
Is grapefruit good for high blood pressure?
Citrus fruits, including grapefruit, oranges, and lemons, may have powerful blood-pressure-lowering effects. They’re loaded with vitamins, minerals, and plant compounds that may help keep your heart healthy by reducing heart disease risk factors like high blood pressure ( 4 ).
Is it OK to eat grapefruit with blood pressure medicine?
Grapefruit contains compounds that may interfere with how your body absorbs some drugs, including some blood pressure medicines. It can leave too much or too little of the drug in your bloodstream, which may be dangerous. Always ask your doctor or pharmacist if grapefruit could affect the medicine you’re taking.
What vitamins should not be taken with grapefruit?
Taking grapefruit with other supplements with similar effects might increase the risk for a serious heart issue. Examples of supplements with this effect include bitter orange, ephedra, iboga, and Panax ginseng. Drinking grapefruit juice when taking licorice might increase licorice’s ability to lower potassium levels.
How long does it take for grapefruit to inhibit CYP3A4?
Why does grapefruit interact with some drugs?
Grapefruit contains compounds known as furanocoumarins that block the CYP3A4 enzymes. When grapefruit juice is consumed, the enzyme’s ability to break down the drug for elimination is decreased. Blood levels of the drug may rise, resulting in a risk for new or worsened side effects.
Does grapefruit raise blood pressure?
How long until grapefruit is out of your system?
Is orange juice a CYP3A4 inhibitor?
Seville orange juice, a constituent of marmalade, also has been shown to inhibit CYP3A4. Regular orange juice, however, has no effect on the enzyme. In addition, limited data suggest that lime, star fruit, and pomegranate juice may reduce CYP3A4 activity.
Can I take Vit D with grapefruit?
Drug and food interactions Grapefruit juice can significantly increase the blood levels and effects of medications like felodipine. You may be more likely to experience side effects such as headache, low blood pressure, irregular heartbeat, swelling, and fluid retention.
