What type of cancer is MDA-MB-231?
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What type of cancer is MDA-MB-231?
The MDA-MB-231 cell line is an epithelial, human breast cancer cell line that was established from a pleural effusion of a 51-year-old caucasian female with a metastatic mammary adenocarcinoma1 and is one of the most commonly used breast cancer cell lines in medical research laboratories.
What is MDA-MB-231 cells?
HTB-26™ MDA-MB-231 are epithelial cells isolated from the breast tissue of a 51-year-old, White, female adenocarcionma patient. Use these cells in your cancer and immuno-oncology research. Cell type epithelial cell Morphology epithelial Tissue Breast; Mammary gland Disease.
What is MCF7 cell line?
1 MCF-7 human adenocarcinoma cells. MCF-7 is a human breast cancer cell line with estrogen, progesterone and glucocorticoid receptors [26]. It is derived from the pleural effusion of a 69-year-old Caucasian metastatic breast cancer (adenocarcinoma) in 1970 by Dr Soule of the Michigan Cancer Foundation, Detroit, MI [27] …
What is the difference between mcf7 and MDA-MB-231?
The MCF-7 cell line has functional estrogen and EGF receptors, is dependent on estrogen and EGF for growth, and is uninvasive, while MDA-MB-231 cells are a model for more aggressive, hormone-independent breast cancer.
What is the difference between MCF7 and MDA-MB-231?
Is MCF-7 invasive?
Though MCF7 is categorized as poorly invasive, its migration in the 2D surface is found to be comparable to the highly invasive MDA MB 231 in the current study.
Do MCF-7 cells have HER2?
Two particularly important members of this large family are the epidermal growth factor receptor (EGFR), which is activated by the epidermal growth factor (EGF), and the human epidermal growth factor receptor-2 (HER2), both present in MCF-7 cells (7).
Where is HEK293 from?
HEK293 is a cell line derived from human embryonic kidney cells grown in tissue culture. They are also known, more informally, as HEK cells. This particular line was initiated by the transformation and culturing of normal HEK cells with sheared adenovirus 5 DNA.
Does MCF-7 have HER2?
What is the difference between MCF-7 and MDA-MB-231?
MCF7 and MDA-MB-231 cells represent a striking example in that they are both invasive ductal/breast carcinoma cells, yet they have many phenotypic/genotypic differences: MCF7 are hormone dependent (both estrogen and progesterone receptor positive—ER and PR), while MDA-MB-231 are triple negative.
Are SKBR3 cells metastatic?
3), indicating that SKBR3/c-Jun derived cells formed tumors, and metastasized to the liver.
