How does the parvovirus replicate?

How does the parvovirus replicate?

Parvoviruses replicate their genome via rolling hairpin replication, a unidirectional, strand displacement form of DNA replication that is initiated by NS1. Replication begins once NS1 binds to and makes a nick in a replication origin site in the duplex DNA molecule at the end of one hairpin.

Which of the following viruses uses the rolling hairpin model to replicate its nucleic acid?

DNA replication in poxviruses uses a “rolling hairpin” model, similar to the method used by viruses in which of the following families?

What is the genetic material in the parvovirus?

Canine parvovirus (CPV) belongs to the genus Protoparvovirus and the family Parvoviridae and causes a highly contagious and fatal disease in dogs [1]. CPV is a non-enveloped DNA virus with an approximately 5000-nucleotide, single-stranded DNA genome containing two open reading frames (ORFs).

Is parvovirus an RNA or DNA virus?

The parvoviruses (parvo meaning small) are a group of very small DNA viruses that are ubiquitous and infect many species of animals. The small amount of DNA contained in the viruses does not carry sufficient genetic information to direct its own replication in host cells.

Where can parvovirus reproduce?

Canine Parvovirus Infection One gram of feces from an acutely infected dog is thought to contain enough viral material to infect over 10 million susceptible dogs by oral exposure. The virus replicates initially in oropharyngeal lymphoid tissue and is then thought to spread via plasma.

What type of cells does parvovirus infect?

The human parvovirus B19 virus replicates only in human erythroid progenitor cells, and cell binding and infection require the erythrocyte P antigen (globoside) (10).

What is hairpin DNA?

A hairpin loop is an unpaired loop of messenger RNA (mRNA) that is created when an mRNA strand folds and forms base pairs with another section of the same strand. The resulting structure looks like a loop or a U-shape. Hairpins are a common type of secondary structure in RNA molecules.

What viruses use rolling circle replication?

Hepatitis delta virus (HDV) contains a viroid-like circular RNA that is presumed to replicate via a rolling circle replication mechanism mediated by cellular RNA polymerases.

What type of organism is parvovirus?

Canine parvovirus (CPV) is a highly contagious viral disease of dogs that commonly causes acute gastrointestinal illness in puppies.

What cells does parvovirus infect?

What pathogen causes parvovirus?

What causes parvovirus infection? The virus that causes the disease known as “parvo”, canine parvovirus type 2 (CPV), first emerged among dogs in Europe around 1976. By 1978 the virus had spread unchecked, causing a worldwide epidemic of myocarditis and inflammation in the intestines (gastroenteritis).

How long can parvovirus live on surfaces?

5-6 months
Infection with parvovirus occurs when a puppy is exposed to contaminated feces or to an object, such as shoes or a sidewalk, which has been contaminated by feces. The virus can live on contaminated surfaces or clothing for up to 5-6 months. Parvovirus becomes widespread throughout the body in 3-4 days.

Can a dog get parvo twice?

Once an animal has recovered from the parvovirus it is not likely they will get it again. Immunity to the disease after infection lasts for several years. Most dogs that recover from the disease have no lasting long term problems as a result of their illness.

Why hairpins are formed in DNA?

mRNA hairpins can be formed when two complementary sequences in a single mRNA molecule meet and bind together, after a folding or wrinkling of the molecule. Hairpin loops can also form in DNA molecules, but are most commonly observed in mRNA.

Where does rolling circle replication occur?

Rolling circle replication is a process which a circular DNA or RNA molecule is replicated in one direction. This particular process occurs in plasmid and virus’s genome.

What is circular Dsdna?

Circular and Double stranded means that the DNA is double stranded and has no terminal ends or rather is a circle. Similarly, not all double stranded DNA have to be circular, human DNA to be the case in point.

What causes parvovirus?

Parvovirus B19 and Other Illnesses. Parvovirus B19 can cause severe anemia (a condition in which the body doesn’t have enough healthy red blood cells). This is not very common but can be serious for people with. weakened immune systems. sickle cell disease or similar long-lasting anemia.