How is nimodipine given?
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How is nimodipine given?
Nimodipine comes as a capsule and an oral solution (liquid) to take by mouth or be given through a feeding tube. It is usually taken every 4 hours for 21 days in a row. Treatment with nimodipine should be started as soon as possible, no later than 96 hours after a subarachnoid hemorrhage occurs.
Why is nimodipine used for SAH?
Nimodipine is used to decrease problems due to a certain type of bleeding in the brain (subarachnoid hemorrhage-SAH). Nimodipine is called a calcium channel blocker. The body naturally responds to bleeding by narrowing the blood vessel to slow blood flow.
What is the name of the oral suspension alternative for nimodipine?
About NYMALIZE Nymalize is the first and only FDA-approved ready-to-use oral solution of nimodipine. This solution offers an effective alternative to capsule extraction for SAH patients who cannot swallow capsules. Nymalize is available in a 473mL (16 oz) bottle and 20mL (60mg), and 10mL (30mg) unit dose cups.
How does nimodipine work in vasospasm?
Nimodipine. Nimodipine is a dihydropyridine agent that blocks voltage-gated calcium channels and has a dilatory effect on arterial smooth muscle. It is the only FDA-approved agent for vasospasm with a half-life of about 9 h [6].
Does nimodipine lower heart rate?
Common side effects may include: low blood pressure (feeling light-headed); nausea, upset stomach; slow heartbeats; or.
What is the recommended treatment for SAH?
Pain medication will be given to alleviate headache, and anticonvulsant medication may be given to prevent or treat seizures. If the SAH is from a ruptured aneurysm, surgery may be performed to stop the bleeding. Options include surgical clipping or endovascular coiling.
How is vasospasm treated after SAH?
Nimodipine has been recommended as first-line medical treatment for preventing post-aSAH cerebral vasospasm. It is usually given orally at a dosage of 60 mg every 4 hours for 21 days after the initial subarachnoid hemorrhage.
Which medication is commonly used to improve neurological outcomes after subarachnoid hemorrhage?
Calcium channel blockers have been shown to reduce the incidence of ischemic neurologic deficits, and nimodipine has been shown to improve overall outcome within 3 months of aneurysmal SAH.
How long does nimodipine take to work?
After oral administration, peak plasma concentration occurs within 1 hour. The elimination half-life is longer (8 to 9 hours) than the rate of initial elimination (1 to 2 hours), making the biological half-life 1.7 to 9 hours. Hence the drug has to be administered frequently (every 4 hours).
Why does nimodipine prevent vasospasm?
Nimodipine is a dihydropyridine agent that blocks voltage-gated calcium channels and has a dilatory effect on arterial smooth muscle. It is the only FDA-approved agent for vasospasm with a half-life of about 9 h [6].
When do you start nimodipine for SAH?
Nimodipine should start as early as possible or within 96 hours of the diagnosis of subarachnoid hemorrhage. The recommended dose for adults is 60 mg (two 30-mg capsules) every 4 hours for 21 consecutive days.
What is gold standard for cerebral vasospasm?
Angiography of the vessels of the brain is the gold standard for the diagnosis of cerebral vasospasm. However, this procedure is invasive, requires the availability of significant resources, and may cause vessel dissection or thrombosis.
How do you prevent vasospasm after SAH?
What is the most common adverse event associated with nimodipine?
Adverse experiences were reported by 92 of 823 patients with subarachnoid hemorrhage (11.2%) who were given nimodipine. The most frequently reported adverse experience was decreased blood pressure in 4.4% of these patients.
Why is nimodipine used in vasospasm?
What procedure is used to treat cerebral vasospasm?
Treatment for vasospasm can occur through both ICU intervention and endovascular administration of intra-arterial vasodilators and balloon angioplasty. The best outcomes are often attained when these methods are used in conjunction.
