What does oncomine mean?
Table of Contents
What does oncomine mean?
ONCOMINE: A Cancer Microarray Database and Integrated Data-Mining Platform – PMC.
What happened oncomine database?
The oncomine database is shutting down by January 17th 2022, in the meantime I couldn’t register in the database, I kept getting errors when trying.
What is oncomine focus assay?
The Oncomine Focus Assay is a targeted next-generation sequencing (NGS), multi-biomarker assay that enables the detection of variants across 52 cancer-relevant genes from DNA and RNA in a single workflow.
How is gene fusion detected?
After mapping, gene fusions can be detected based on a combination of these split and discordant reads to the partner genes. Gene fusions can also be detected from DNA sequencing data, especially for fusions that are difficult to detect from RNA-seq due to their low expression.
What is fusion gene analysis?
Fusion genes are hybrid genes generated by the juxtaposition of two previously independent genes, following structural rearrangements like deletions, inversions, translocations or duplications within the same chromosome or between different chromosomes [1].
What is fusion detection?
Background. Accurate fusion transcript detection is essential for comprehensive characterization of cancer transcriptomes. Over the last decade, multiple bioinformatic tools have been developed to predict fusions from RNA-seq, based on either read mapping or de novo fusion transcript assembly.
What causes genes to fuse?
Gene fusions are hybrid genes formed when two previously independent genes become juxtaposed. The fusion can result from structural rearrangements like translocations and deletions, transcription read-through of neighboring genes (1–3), or the trans- and cis-splicing of pre-mRNAs (4–8) (Figure 1).
How do you identify fusion genes?
To determine fusion candidates, most of the methods use discordant reads such as spanning read pairs and/or split reads. Spanning reads contain one read located in different genes, while split reads indicates a single read overlapping on two different genes.
What is fusion DNA?
(FYOO-zhun jeen) A gene made by joining parts of two different genes. Fusion genes, and the fusion proteins that come from them, may be made in the laboratory, or made naturally in the body when part of the DNA from one chromosome moves to another chromosome.
What is RNA fusion?
Fusion transcript is a chimeric RNA encoded by a fusion gene or by two different genes by subsequent trans-splicing. Certain fusion transcripts are commonly produced by cancer cells, and detection of fusion transcripts is part of routine diagnostics of certain cancer types.
What type of mutation is fusion?
Gene fusions, or translocations, resulting from chromosomal rearrangements are the most common mutation class. They lead to chimeric transcripts or to deregulation of genes through juxtapositioning of novel promoter or enhancer regions.
What causes gene fusion?
What is a fusion mutation?
What causes gene fusions?
What is Oncomine?
Here, we present ONCOMINE, a cancer microarray database and web-based data-mining platform aimed at facilitating discovery from genome-wide expression analyses. To date, ONCOMINEcontains 65 gene expression datasets comprising nearly 48 million gene expression measurements form over 4700 microarray experiments.
How can Oncomine be used to assess the differential expression of genes?
Typically, researchers use a single microarray dataset to identify a set of genes that are associated with a particular cancer type or subtype. With ONCOMINE, users can now assess and visualize the differential expression of a selected gene across all available datasets and differential expression analyses.
Why Oncomine solutions for precision oncology?
That’s why Oncomine Solutions offer choices and complete end to end solutions for fast profiling of key biomarkers as well as comprehensive genomic profiling or other applications. Learn about the latest in Oncomine NGS solutions for precision oncology.
What is the Oncomine Comprehensive Assay plus?
Requiring only 20 ng FFPE sample input, the Oncomine Comprehensive Assay Plus helps minimize these barriers to testing.
