What is Glucuronidation metabolism?

What is Glucuronidation metabolism?

n. a metabolic process by which drugs or other substances are combined with glucuronic acid to form more water-soluble compounds, which are more readily excreted by the kidneys or in bile. Glucuronidation is the most prevalent of the Phase II reactions of drug metabolism.

What is sulfation in biology?

Sulfation is an important pathway of metabolism for a range of endogenous compounds including steroid hormones, bile acids, neurotransmitters, and small peptides. Xenobiotics also undergo conjugation by sulfation, which generally, but not exclusively, leads to reduced biological activity.

What causes sulfation?

Sulfation occurs when a battery is deprived of a full charge, it builds up and remains on battery plates. When too much sulfation occurs, it can impede the chemical to electrical conversion and greatly impact battery performance.

What is the difference between sulfonation and sulfation?

Sulfonation and sulfation are two important chemical processes used in many industries to add a sulfur-containing group to an organic compound. The main difference between sulfonation and sulfation is that sulfonation involves the formation of a C-S bond whereas sulfation involves the formation of a C-O-S bond.

What is sulfonation process?

Sulfonation is the term that identifies an electrophilic chemical reaction where a sulfonic group SO3H is incorporated into a molecule with the capacity to donate electrons. The product of this chemical reaction is recognized as sulfonic acid if the electron donor molecule is a carbon.

What is sulfation reaction?

Sulfation reactions, which involve the transfer of the sulfate group from 5′-phosphoadenosine 3′-phosphosulfate to an appropriate functional group, for example, hydroxyl or amino, are catalyzed by a family of sulfotransferase (SULT) isoenzymes present in the cytosol of most tissues including the kidney.

How do I stop sulfation?

To prevent sulfation during storage a battery must be kept at a charge of at least 12.4 volts and be stored in an environment where temperatures do not exceed 75°F (24°C). For every 10°F increase above this temperature the rate of self-discharge of the battery doubles.

How can you prevent sulfation?

One of the easiest ways to prevent battery sulfation is proper battery storage. When a battery is stored, even if it’s stored at a full charge, a battery must be charged enough to prevent it from dropping below 12.4 volts. Applying this maintenance charge will prevent sulfates from building up.