What is meant by Lipogranuloma?

What is meant by Lipogranuloma?

Lipogranuloma is a granulomatous inflammatory soft tissue reaction, consisting of lipid deposition and/or an oil-like substance commonly associated with injections, trauma or secondary to systemic diseases.

What is lipogranulomas in liver?

Terminology. Lipogranuloma is due to histiocytic reaction to lipid aggregate. Steato-fibrosis is typically seen in around the hepatocytes and central venules more commonly seen in fatty liver disease.

What is granulomas in the spleen?

Splenic granulomas present as single or multiple hypodense lesions on CT. These lesions are usually caused by M. tuberculosis infection and very rarely due to MAC. 6. Splenic granulomas may be seen in association with disseminated MAC infections.

What is histopathological granuloma?

Granulomatous inflammation is a histologic pattern of tissue reaction which appears following cell injury. Granulomatous inflammation is caused by a variety of conditions including infection, autoimmune, toxic, allergic, drug, and neoplastic conditions.

What is Mallory’s hyaline?

Mallory bodies (Mallory hyaline) are irregular, ropelike eosinophilic intracytoplasmic strings that represent aggregates of cytokeratin intermediate filaments (cytokeratins 8 and 18).

Are splenic granulomas common?

The differential diagnosis for these lesions includes sarcoidosis and other granulomatous infections [27]. Calcified splenic granulomas are a common incidental finding, most commonly resulting from tuberculosis or histoplasmosis and less commonly from Pneumocystis carinii pneumonia or brucellosis [29, 30].

What are the symptoms of granulomatous disease?

Symptoms

• Fever.
• Chest pain when inhaling or exhaling.
• Swollen and sore lymph glands.
• A persistent runny nose.
• Skin irritation that may include a rash, swelling or redness.
• Swelling and redness in your mouth.

Can granulomatous disease be cured?

Treatment. People with CGD take lifelong regimens of antibiotics and antifungals to prevent infections. Injections with interferon gamma, a protein that improves the activity of phagocytes, also may help reduce the number of severe infections. Abscesses need aggressive care that may include surgery.

In what disease is Mallory bodies encountered?

Mallory bodies are classically found in the livers of people suffering from alcohol-induced liver disease and were once thought to be specific for that. They are most common in alcoholic hepatitis (prevalence of 65%) and alcoholic cirrhosis (prevalence of 51%).

Why do Mallory bodies form?

Mallory Bodies These inclusions are composed in part of various polypeptides and cytokeratins, and result from damage of the intermediate filaments in the liver cell cytoplasm due most frequently to chronic alcohol usage.

What does calcified granulomas in the spleen mean?

Calcified granulomas can form in the spleen due to TB bacterial infection or the fungal infection histoplasmosis. Sarcoidosis is a noninfectious cause of granulomas in the spleen.

What causes calcified granulomas in the spleen?

Calcified splenic granulomas are a common incidental finding, most commonly resulting from tuberculosis or histoplasmosis and less commonly from Pneumocystis carinii pneumonia or brucellosis [29, 30]. A risk factor for many of these infections is HIV infection.

How long can you live with granulomatous disease?

CGD was initially termed “fatal granulomatous disease of childhood” because patients rarely survived past their first decade in the time before routine use of prophylactic antimicrobial agents. The average patient now survives at least 40 years.

What do Mallory bodies indicate?

Mallory-Denk Bodies (MDB) are important as investigators, suggesting MDB as an indicator of the histologic severity of chronic hepatitis, causes of which include hepatitis C, primary biliary cirrhosis (PBC), and nonalcoholic fatty liver disease (NAFLD).

What causes an enlarged spleen and how is it treated?

It can happen for many reasons, including problems with too many platelets and other disorders of the blood. An enlarged spleen can be caused by infections, cirrhosis and other liver diseases, blood diseases characterized by abnormal blood cells, problems with the lymph system, or other conditions. Here are some common causes of an enlarged spleen:

What is splenomegaly and how is it treated?

Splenomegaly is a condition that occurs when your spleen becomes enlarged. It’s also commonly referred to as enlarged spleen or spleen enlargement. The spleen is a part of your lymphatic system.

What does an enlarged spleen feel like?

If you’re very slim, it may be possible for you to feel your enlarged spleen through your skin. A common symptom of an enlarged spleen is a feeling of pain or discomfort in the upper left side of abdomen, where the spleen is located. You might also experience a feeling of fullness after only eating a small amount.

How do I know if I have splenomegaly?

Splenomegaly can usually be felt during an examination by a healthcare provider. What is the spleen? The spleen is an organ that is located in the upper abdomen.