What is meperidine metabolite?

What is meperidine metabolite?

MEPERIDINE hydrochloride is an opioid frequently used to treat acute pain. Normeperidine is its only metabolite that has significant pharmacologic activity. 1. Accumulation of normeperidine can occur and is strongly associated with central nervous system (CNS) excitation.

What is Demerol metabolized?

Anesthesia for the Surgeon Meperidine (Demerol) has a unique profile in that it has a toxic metabolite, normeperidine, that has a longer half-life than the parent drug but no analgesic effects. Normeperidine can accumulate to toxic levels in patients with hepatic or renal dysfunction.

How is Demerol cleared?

Meperidine is metabolized in the liver and undergoes N-demethylation to produce the active metabolite, normeperidine, which is excreted via the kidneys. The elimination half-life of meperidine is 2.4 to 4 hours in normal patients and extends to 7 to 11 hours in patients with hepatic dysfunction.

Is meperidine used in PCA?

The opioid most commonly utilized in IV PCA is morphine, although other opioids have often been used as well, including hydromorphone, fentanyl, and meperidine (TABLE 1).

Where is meperidine metabolized?

Meperidine is metabolized in the liver by hydrolysis to meperidinic acid followed by partial conjugation with glucuronic acid. Meperidine also undergoes N-demethylation to normeperidine, which then undergoes hydrolysis and partial conjugation.

Where is Demerol metabolized?

Meperidine is metabolized chiefly in the liver, with a half-life of ~3 hours.

How do you inject Demerol?

Meperidine injection comes as a solution (liquid) to inject subcutaneously (just under the skin), intramuscularly (into a muscle), or intravenously (into a vein). It is usually injected subcutaneously or intramuscularly once every 3 to 4 hours as needed.

What is the indication of meperidine?

DEMEROL is indicated for the relief of moderate to severe pain. DEMEROL is contraindicated in patients with hypersensitivity to meperidine. Meperidine is contraindicated in patients who are receiving monoamine oxidase (MAO) inhibitors or those who have recently received such agents.

What is the chemical name for Demerol?

DEMEROL (meperidine hydrochloride, USP) Tablet and Oral Solution are opioid agonists. DEMEROL Tablets are available as 50 mg and 100 mg Tablets for oral administration. The chemical name is 4-Piperidinecarboxylic acid, 1-methyl-4-phenyl-,ethyl ester, hydrochloride. The molecular weight is 283,80.

Where do you give Demerol injection?

A nurse or other trained health professional will give you this medicine in a hospital. This medicine is given through a needle placed in one of your veins, or as a shot under your skin or in a muscle. Meperidine may sometimes be given at home to patients who do not need to be in the hospital or clinic.

What is the purpose of PCA?

PCA helps you interpret your data, but it will not always find the important patterns. Principal component analysis (PCA) simplifies the complexity in high-dimensional data while retaining trends and patterns. It does this by transforming the data into fewer dimensions, which act as summaries of features.

What metabolite means?

Listen to pronunciation. (meh-TA-boh-lite) A substance made or used when the body breaks down food, drugs or chemicals, or its own tissue (for example, fat or muscle tissue). This process, called metabolism, makes energy and the materials needed for growth, reproduction, and maintaining health.

How do metabolites work?

Some drugs, called prodrugs, are administered in an inactive form, which is metabolized into an active form. The resulting active metabolites produce the desired therapeutic effects. Metabolites may be metabolized further instead of being excreted from the body. The subsequent metabolites are then excreted.