What is NAA Brain Spectroscopy?

What is NAA Brain Spectroscopy?

N-acetylaspartate (NAA) is one of the more important compounds assessed on MR spectroscopy, and resonates at 2.0 ppm chemical shift (its concentration in healthy adults is 8-10 mM) 1. The synthesis of NAA, adenosine diphosphate-dependent, occurs in the neuronal mitochondria 2.

Which peak on MR spectroscopy is seen in Tuberculoma?

MR spectroscopy of intracranial tuberculomas: A singlet peak at 3.8 ppm as potential marker to differentiate them from malignant tumors.

HOW IS MR spectroscopy performed?

MR spectroscopy is conducted on the same machine as conventional MRI. The MRI scan uses a powerful magnet, radio waves, and a computer to create detailed images. Spectroscopy is a series of tests that are added to the MRI scan of your brain or spine to measure the chemical metabolism of a suspected tumor.

What is choline peak?

Choline peak in brain MRS is a cell membrane marker and its elevation indicates high cellularity or cell destruction as seen in most neoplastic lesions, however can be seen in infections (Tubercular and fungal infections) and inflammatory disorders (demyelination) 1, 3, 4, 5.

WHAT IS MR spectroscopy used for?

While magnetic resonance imaging (MRI) identifies the anatomical location of a tumor, MR spectroscopy compares the chemical composition of normal brain tissue with abnormal tumor tissue. This test can also be used to detect tissue changes in stroke and epilepsy.

What is NAA level?

Background: NAA, marker of neurons integrity and viability, is one of the most important brain metabolites visible in 1H MRS. In most studies of schizophrenia, the decrease of NAA level was observed in the temporal, frontal lobes and in the thalamus.

How can you tell the difference between NCC and TB?

The patient responded well to the treatment and fully recovered. In conclusion, the distinction between NCC and tuberculoma is important because parenchymal cysticercosis is a benignand self-limiting condition, whereas tuberculoma is anactive infection requiring prolonged therapy that involvespotentially toxic drugs.

How do you calculate choline creatine ratio?

In turn, the Cho/Cr ratio (R) for the AUCs was calculated using the formula R = PHCho × FWHMCho/(PHCr × FWHMCr). Cho/Cr ratios were determined for TEs of 136 and 272 for all three groups of tissue samples.

How accurate is MR spectroscopy?

The overall MRS diagnosis of the all studied neoplastic and neoplastic lesions is approximately 95.3% sensitivity, 97.1% specificity, and 96% accuracy.

What does an MRI spectroscopy show?

What is an inverted lactate peak?

A lactate peak was identified as an inverted doublet peak at TE = 144 ms. A negative peak in the left component, occurring with a decreased negative peak in the right component, and a positive peak at 1.3 ppm, was defined as combined lac and lip (lac/lip). Clear upward peaks at 1.3 and 0.9 were defined as lipid.

How long does MR spectroscopy take?

The scan usually takes about 45 to 60 minutes to complete. Some spectroscopy studies may take longer if more pictures are needed. You need to lie very still while each set of scans is being done. Any movement will affect the results.

What is magnetic resonance spectroscopy used for?

Magnetic resonance spectroscopy (MRS) is a noninvasive technique that can be used to measure the concentrations of different chemical components within tissues.

What does N acetyl aspartate do?

Evidence suggests that NAA is a direct precursor for the enzymatic synthesis of the neuron specific dipeptide N-acetylaspartylglutamate, the most concentrated neuropeptide in the human brain. Other proposed roles for NAA include neuronal osmoregulation and axon-glial signaling.

How is MRI Tuberculoma different from NCC?

Results: NCC cases showed no lipid peak whereas tuberculoma lesions except one showed predominant lipid peaks. Both lesions showed reduced N-acetylaspartate (NAA) levels. NCC lesions showed acetate/succinate or both peaks whereas these metabolites were normal in tuberculoma lesions.

What are the three most important lesions in the differential diagnosis of a ring enhancing mass?

The differential for peripheral or ring enhancing cerebral lesions includes: cerebral abscess. tuberculoma. neurocysticercosis.

What is Mrs test?

Magnetic resonance spectroscopy (MRS), also known as nuclear magnetic resonance (NMR) spectroscopy, is a non-invasive analytical technique that has been used to study metabolic changes in brain tumors, strokes, seizure disorders, Alzheimer’s disease, depression and other diseases affecting the brain.

How can you distinguish between lipid and lactate peak?

HOW MUCH DOES MR spectroscopy cost?

It is a non-invasive and painless method to visualize the brain. Book this really important test at your local top quality labs through us at up to 50% discount….MR Spectroscopy Cost in India and Lab Details.

MR Spectroscopy Labs & Book Appointment	Price Starting From
MR Spectroscopy Price in Delhi	₹2500

How long does a magnetic resonance spectroscopy take?

With modern 3T MRI systems it is possible to obtain a 16 × 16 × 16 array of spectra with a voxel size of 1 cm3 in 5 to 10 min.