What is Sca-1 marker?

What is Sca-1 marker?

Sca-1 is the most common marker used to enrich adult murine hematopoietic stem cells (HSCs) [14, 15] and can be used to isolate a nearly pure HSC population when used in conjunction with additional markers [16, 17].

What cells express Sca1?

Stem cell antigen-1 (Sca1) is expressed on murine hematopoietic stem cells, and it is a commonly-used marker of these cells [1].

What is an LSK cell?

KSL cells in cell biology are an early form of mouse/murine hematopoietic stem cells. Characteristics are Kit (+), Sca-1 (+) and Lin (-). HSCs [Hematopoietic stem cells] in murine cultures show phenotypic markers as being CD34-, CD150+, and Flt3- for LTR [long-term reconstitution].

What is spinocerebellar ataxia type 1?

Spinocerebellar ataxia type 1 (SCA1) is a condition characterized by progressive problems with movement. People with this condition initially experience problems with coordination and balance (ataxia).

Is HSC pluripotent?

There is strong evidence for the concept that HSCs are pluripotent and are the source for the majority, if not all, of the cell types in our body.

What is long term HSC?

Long term HSCs are capable of self renewal, while short term HSCs do not have this capacity. Short term HSCs, also called progenitor or precursor cells, can differentiate into all types of blood cells, which can be characterized by specific markers.

Is SCA genetic?

SCA is hereditary, progressive, degenerative, and often fatal. There is no known effective treatment or cure. SCA can affect anyone of any age. The disease is caused by either a recessive or dominant gene.

Is SCA an autoimmune disease?

SCA is hereditary, progressive, degenerative, and often fatal. There is no known effective treatment or cure. SCA can affect anyone of any age. The disease is caused by either a recessive or dominant gene….