What is the difference between intrinsic and extrinsic pathways in blood clotting?
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What is the difference between intrinsic and extrinsic pathways in blood clotting?
The intrinsic pathway is activated through exposed endothelial collagen, and the extrinsic pathway is activated through tissue factor released by endothelial cells after external damage. This pathway is the longer pathway of secondary hemostasis.
Which clotting factors are involved in the intrinsic and extrinsic pathways?
Clotting factors involved in the intrinsic pathway include factors XII, XI, IX, and VIII. Clotting factors involved in the extrinsic pathway include factors VII, and III. The common pathway includes clotting factors X, V, II, I, and XIII.
What is the intrinsic pathway of clotting?
The term intrinsic pathway refers to a series of sequential reactions involving the plasma proteins factors VIII, IX, XI and XII; and pre-kallikrein and high molecular weight kininogen that are required for initiation of coagulation in the activated partial thromboplastin time (aPTT) assay.
What is extrinsic clotting pathway?
The extrinsic pathway consists of the transmembrane receptor tissue factor (TF) and plasma factor VII/VIIa (FVII/FVIIa), and the intrinsic pathway consists of plasma FXI, FIX, and FVIII. Under physiological conditions, TF is constitutively expressed by adventitial cells surrounding blood vessels and initiates clotting.
What is difference between intrinsic and extrinsic?
Intrinsic motivation involves doing something because it’s personally rewarding to you. Extrinsic motivation involves doing something because you want to earn a reward or avoid punishment.
What is difference between extrinsic and intrinsic system?
The extrinsic system operates as the result of activation by tissue lipoprotein, usually released as the result of some mechanical injury or trauma. The intrinsic system usually involves circulating plasma factors. Both of these pathways come together at the level of factor X, which is activated to form factor Xa.
What are intrinsic and extrinsic factors?
While intrinsic factors act from within an individual, extrinsic factors wield their influence from the outside (i.e., they are environmental, cultural, or related to lifestyle). Extrinsic factors can have a sizeable impact on a person’s health and can affect medical decision-making.
Why is intrinsic pathway of coagulation called intrinsic?
The intrinsic pathway of blood coagulation is so named due to the presence of all the required reactants of this pathway in the circulation, with no external protein source required (unlike the extrinsic pathway that requires exposure to extravascular tissue factor for triggering).
Why is it called intrinsic pathway?
What are intrinsic rewards?
An intrinsic reward is an internal reward that employees achieve from completing their tasks or projects successfully. These rewards are mostly psychological and are based on the effort and abilities of a person.
What is the difference between extrinsic reward and intrinsic reward?
When talking about rewards, intrinsic rewards are those that originate from within the person, and extrinsic rewards are those that originate from something beyond the person.
What are extrinsic rewards?
Extrinsic rewards are usually financial or tangible rewards given to employees, such as pay raises, bonuses, and benefits. They are extrinsic because they are external to completing the work itself and are controlled by people other than the employee.
Which of the following is a difference between extrinsic rewards and intrinsic rewards?
Extrinsic rewards—including pay, material goods, and social recognition—are granted by others. Intrinsic rewards are psychic rewards, such as a sense of competence or a feeling of accomplishment, that are self-granted and experienced internally.
Is PTT intrinsic or extrinsic?
PTT measures the integrity of the intrinsic system (Factors XII, XI, VIII, IX) and common clotting pathways. Increased levels in a person with a bleeding disorder indicate a clotting factor may be missing or defective.
How do you remember APTT and PT?
APTT (35-45 seconds) The activated partial thromboplastin time (APTT) is a measure of the time taken for blood to clot via the intrinsic pathway (a good way to remember, following PT, is that you ‘Play Table Tennis INSIDE’ therefore PTT is INTRINSIC).
Why is it called intrinsic and extrinsic pathway?
Does intrinsic and extrinsic pathway occur at the same time?
Both the intrinsic and extrinsic pathways come together in the common pathway, which involves the FXa-mediated generation of thrombin from prothrombin and subsequent generation of fibrin from fibrinogen.
What are extrinsic and intrinsic rewards?
Extrinsic rewards include tangible rewards such as a monetary bonus or an extra day off of work. They are controlled by people other than you. Intrinsic rewards are intangible, psychological rewards that you get from a job well done.
