What is the therapeutic blood level for Depakote?

What is the therapeutic blood level for Depakote?

Reference Range Depakote The reference ranges for valproic acid are as follows: The therapeutic range for valproic acid (total) is 50-125 µg/mL. The toxic level is greater than 150 µg/mL. The therapeutic range for valproic acid (free) is 6-22 µg/mL.

What is a therapeutic valproate level?

The therapeutic range for valproic acid is 50-100 mcg/mL. The toxic level is >100 mcg/mL.

How long does it take Depakote to reach therapeutic level?

Tablets take 4 hours to reach a peak, Depakote sprinkles take just over three. Food can delay the absorption of Depakote (food has a more significant effect on the tablets compared with the sprinkles). It may take several weeks of regular dosing before an effect on mood or seizure frequency is reported.

When should you get a Depakote level?

In general, when taking divalproex-ER once daily in the morning, a blood sample collected at 21-24 h after OD dose of ER preparation is expected to have a concentration within 3% of the trough value.

What happens if valproic acid levels are too high?

Taking too much valproic acid can lead to symptoms such as: feeling or being sick (nausea or vomiting) headaches, or feeling dizzy. muscle weakness.

What is the therapeutic level?

The therapeutic level of a drug in the bloodstream is the range within which that drug is expected to be effective. Your doctor can request a test to measure the amount of a specific drug in the serum portion of your blood.

Do Depakote levels need to be monitored?

Patients should be monitored closely for appearance of these symptoms. Serum liver tests should be performed prior to therapy and at frequent intervals thereafter, especially during the first six months [see Warnings and Precautions (5.1)].

How much is too much valproic acid?

Adults—At first, 250 milligrams (mg) 2 times a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 1000 mg a day.

Is 1250 mg of Depakote too much?

The starting dosage of Depakote tablets is 250 mg twice per day. Your doctor may increase your dose up to a maximum dose of 1,000 mg/day, as needed.

How often should Depakote levels be monitored?

Monitor Depakote levels, liver function tests, and CBC with diff every 3-6 months.

What is a free valproic acid level?

The generally acceptable range for total valproic acid used as a reference to guide therapy is 50 to 125 mcg/mL. The corresponding range of free valproic acid concentration for clinical reference is 5 to 25 mcg/mL.

Is 1500 mg of Depakote too much?

The starting dosage of Depakote ER tablets is 25 mg per kilogram* of body weight per day (25 mg/kg/day). For example, if you weigh 60 kg (about 132 pounds [lb]), your typical starting dosage would be 1,500 mg/kg/day. The maximum dosage of Depakote and Depakote ER tablets for bipolar disorder is 60 mg/kg/day.

Is 1000 mg of valproic acid a lot?

Is 1000mg of Depakote a lot?

Depakote tablets are administered orally. The recommended starting dose is 250 mg twice daily. Some patients may benefit from doses up to 1,000 mg/day. In the clinical trials, there was no evidence that higher doses led to greater efficacy.

Does Depakote require blood monitoring?

Depakote levels are routinely checked with blood tests to make sure you have neither too little nor too much in your system. Too little will render it ineffective while too much may be toxic.

Do you want a high or low therapeutic index?

The larger the therapeutic index (TI), the safer the drug is. If the TI is small (the difference between the two concentrations is very small), the drug must be dosed carefully and the person receiving the drug should be monitored closely for any signs of drug toxicity.