Which medication is contraindicated in patients with congenital long QT syndrome?
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Which medication is contraindicated in patients with congenital long QT syndrome?
Psychotropics/Antidepressants/ Anticonvulsants The antipsychotics (including Thioridazine, Haloperidol Mesoridazine, chlorpromazine), the antidepressants (including Maptiline, Amitriptyline, imiprmaine, fluoxetine, desipramine, paroxetine) and anticonvulsants Felbamate and Fosphenytoin are to be avoided.
Can salbutamol cause prolonged QT?
Salbutamol is known to cause minimal side effects, which may be under-recognized and progress to serious manifestations such as hypokalemia, QT prolongation, and sudden cardiac death.
Does Albuterol cause QT prolongation?
Conclusion: The data of the present study suggest that the increase of the QTd is more prominent with the use of a standard dose of albuterol compared to low dose albuterol plus ipratropium therapy.
Do antihistamines cause QT prolongation?
Some antihistamines, such as mizolastine and ebastine, can prolong the QT interval and provoke severe cardiac arrhythmias.
What medications can cause prolonged QT?
The most potent QT-prolonging medications are antiarrhythmic agents, particularly amiodarone, dofetilide, quinidine, and sotalol, with quinidine possibly having the most torsadogenic potential.
What antihistamines cause long QT syndrome?
Do antihistamines prolong QT?
Does dobutamine prolong QT?
When dobutamine was infused at a rate of 10 microg/kg/min, the QT interval corrected for heart rate (QTc) was prolonged from 460 ms to 620 ms with abnormal TU complexes and torsades de pointes developed.
Can cetirizine cause QTc prolongation?
We found no reports of QT prolongation attributed to levocetirizine. Cetirizine is a metabolite of hydroxyzine, another antihistamine. In the 1960s, a study of patients with psychosis showed a risk of QT prolongation.
Does cetirizine affect QT interval?
Results: Cetirizine did not lengthen the QT intervals at rest or during exercise and recovery in any group. It shortened Tp-e at rest in LQT1 and LQT2 patients and during exercise test in LQT1 patients, thus slightly decreasing electrocardiographic transmural dispersion of repolarization.
Can you give Zofran with prolonged QTc?
The use of a single 32 mg intravenous dose of ondansetron should be avoided. New information indicates that QT prolongation occurs in a dose-dependent manner, and specifically at a single intravenous dose of 32 mg.
Does rocuronium prolong QTc?
Conclusion. In patients undergoing coronary artery revascularization surgery, rocuronium doses of 0.6 mg kg−1 and 1.2 mg kg−1 prolong the QTc interval after intubation.
Does furosemide cause prolonged QT?
Consistent with their associations with serum potassium, both metolazone and furosemide were associated with mean QTc prolongations of 8 and 4 milliseconds, respectively, without adjustment for electrolytes.
What antihistamine is safe with long QT?
Cetirizine and loratadine: minimal risk of QT prolongation.
Does Atarax prolong QT?
The review concluded that hydroxyzine is associated with a small risk of QT interval prolongation and Torsade de Pointes. Such events are most likely to occur in patients who already have risk factors for QT prolongation, such as: concomitant use of medicines that prolong the QT interval.
Does QTc duration affect asthma comorbidity in LQTS patients?
In conclusion, the occurrence of asthma in LQTS patients increases with QTc duration. Asthma comorbidity in LQTS patients is associated with an increased risk of cardiac events.
Which medications are used to treat LQTS (low QT syndrome)?
Since anxiety and pain can trigger arrhythmias in patients with LQTS, pre-anesthetic medication is recommended. Anesthetic premedication is usually performed using vagolytic and sedative/analgesic drugs. Among these drugs, atropine causes a lengthening of the QT interval and should not be used.
What is long QT syndrome (LQTS)?
Long QT syndrome (LQTS) is a group of disorders that have a prolonged QT interval and a polymorphic ventricular tachycardia. Torsade de pointes (“twisting of the points”) is a particular type of polymorphic ventricular tachycardia that can be associated with LQTS. LQTS can be congenital or acquired.
What drugs to be avoided in patients with C-Long QT syndrome?
Drugs to be avoided in patients with c-long QT syndrome Drugs to be avoided in patients with c-l Drugs to be avoided in patients with c-l Class Generic name Anesthetic Sevoflurane Anti-anginal Ranolazine, Bepridil Anti-arrhythmic Sotalol, Quinidine, Amiodarone, Ibutilid
